Ethyl 4-aminobenzoate , Analysis standard , 94-09-7
Synonym(s):
4-Aminobenzoic acid ethyl ester;Benzocainum;Ethyl 4-aminobenzoate
CAS NO.：94-09-7
Empirical Formula: C9H11NO2
Molecular Weight: 165.19
MDL number: MFCD00007892
EINECS: 202-303-5
| Pack Size | Price | Stock | Quantity |
| 100MG | RMB396.80 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 88-90 °C |
| Boiling point: | 172 °C (12.7517 mmHg) |
| Density | 1.17 |
| refractive index | 1.5600 (estimate) |
| Flash point: | 172°C/13mm |
| storage temp. | 2-8°C |
| solubility | alcohol: soluble1 gm in 5 ml |
| form | Crystalline Powder |
| pka | 2.5(at 25℃) |
| color | White |
| Odor | odorless |
| Water Solubility | Soluble in ethanol, chloroform, ethyl ether and dilute acids. Sparingly soluble in water |
| Merck | 14,1086 |
| BRN | 638434 |
| Stability: | Stable. Combustible. Incompatible with strong oxidizing agents. |
| InChIKey | BLFLLBZGZJTVJG-UHFFFAOYSA-N |
| LogP | 1.860 |
| CAS DataBase Reference | 94-09-7(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzoic acid, 4-amino-, ethyl ester(94-09-7) |
| EPA Substance Registry System | Benzocaine (94-09-7) |
Description and Uses
Benzocaine (ethyl p-aminobenzoate) is used topically by itself or in combination with menthol or
phenol in nonprescription dosage forms such as gels, creams, ointments, lotions, aerosols, and
lozenges to relieve pain or irritation caused by such conditions as sunburn, insect bites,
toothache, teething, cold sores or canker sores in or around the mouth, and fever blisters.
Benzocaine is a lipophilic local anesthetic agent with a short duration of action.
Like most amino ester-type local anesthetics, it is easily hydrolyzed by plasma cholinesterase.
Because of its low pKa, however, it is un-ionized under most physiological conditions and, therefore, can only bind
to the lipid side of the local anesthetic receptor. It also can easily cross membranes
into systemic circulation to cause systemic toxicities. Furthermore, being a PABA derivative, it
has similar allergenic properties to procaine and is contraindicated with sulfonamide antibacterial
agents.
Benzocaine is used as an anesthetic (Local and topical) that in products such as burn and sunburn remedies, hemorrhoidal creams, suppositories, creams for treatment of poison ivy, oral and gingival products, sore-throat sprays/lozenges, astringents, appetite suppressants, callus and wart remedies, athlete's-foot remedies, toothache- and denture-irritation products.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H317 |
| Precautionary statements | P261-P272-P280-P302+P352-P333+P313-P362+P364 |
| Hazard Codes | Xi,T,F |
| Risk Statements | 43-36/37/38-39/23/24/25-23/24/25-11 |
| Safety Statements | 22-24/25-37/39-26-24-45-36/37-16-7 |
| RIDADR | 3077 |
| WGK Germany | 2 |
| RTECS | DG2450000 |
| TSCA | Yes |
| HazardClass | 9 |
| PackingGroup | III |
| HS Code | 29224995 |
| Hazardous Substances Data | 94-09-7(Hazardous Substances Data) |
| Toxicity | LD50 oral in rat: 3042mg/kg |
