Disodium Prednisolone 21-Phosphate , >98.0%(HPLC) , 125-02-0

Synonym(s):
Prednisolone 21-phosphate disodium salt

CAS NO.：125-02-0

Empirical Formula: C21H27Na2O8P

Molecular Weight: 484.39

MDL number: MFCD07776968

EINECS: 204-722-9

PRODUCT Properties

• Melting point: >197°C (dec.)
• alpha: D25 +102.5°
• storage temp.: Inert atmosphere,Room Temperature
• solubility: Freely soluble in water, very slightly soluble in ethanol (96 per cent).
• form: Solid
• color: White to Off-White
• λmax: 243nm(MeOH)(lit.)
• Merck: 14,7721
• Stability: Hygroscopic
• CAS DataBase Reference: 125-02-0(CAS DataBase Reference)
• EPA Substance Registry System: Pregna-1,4-diene-3,20-dione, 11,17-dihydroxy-21-(phosphonooxy)-, disodium salt, (11.beta.)- (125-02-0)

Description and Uses

Prednisolone is a synthetic analog of the natural glucocorticoid corticosterone that has anti-inflammatory and immunsuppressive actions. It avidly binds both glucocorticoid and mineralocorticoid receptors (K_is = 2.4 and 37 nM). Prednisolone Phosphate, prepared as the sodium salt, is a water-soluble ester of the poorly soluble parent molecule, prednisolone. It is rapidly hydrolyzed in vivo to the parent molecule when administered intravenously. In addition, when given orally, prednisolone phosphate is more readily absorbed than prednisolone, resulting in a higher effective blood concentration of prednisolone.

Prednisolone Sodium is a synthetic corticosteroid; metabolically interconvertible with prednisone.

Safety

• Symbol(GHS): GHS08
• Signal word: Danger
• Hazard statements: H360D
• Precautionary statements: P201-P280-P308+P313
• WGK Germany: 3
• RTECS: TU4153300
• HS Code: 2937290000