Prednisolone(Predonine) , ≥98% , 50-24-8

Synonym(s):
1,4-Pregnadiene-11β,17α,21-triol-3,20-dione;11β,17α,21-Trihydroxy-1,4-pregnadiene-3,20-dione;1-Dehydrocortisol;1-Dehydrohydrocortisone;Prednisolone

CAS NO.：50-24-8

Empirical Formula: C21H28O5

Molecular Weight: 360.45

MDL number: MFCD00003649

EINECS: 200-021-7

PRODUCT Properties

• Melting point: 240 °C (dec.) (lit.)
• Boiling point: 412.46°C (rough estimate)
• alpha: D25 +102° (dioxane)
• Density: 1.0963 (rough estimate)
• refractive index: 100 ° (C=1, Dioxane)
• Flash point: 2℃
• storage temp.: 2-8°C
• solubility: Very slightly soluble in water, soluble in ethanol (96 per cent) and in methanol, sparingly soluble in acetone, slightly soluble in methylene chloride. It shows polymorphism (5.9).
• pka: 12.46±0.70(Predicted)
• form: powder
• color: White to Off-White
• Water Solubility: 2.225g/L(25 ºC)
• Merck: 14,7721
• BRN: 1354103
• BCS Class: 1
• InChIKey: OIGNJSKKLXVSLS-VWUMJDOOSA-N

Description and Uses

Prednisolone is the active metabolite of the synthetic corticosteroid prednisone , which is used in the suppression of inflammation and autoimmunity, as well as in other conditions. It alters gene expression through both the glucocorticoid and mineralocorticoid receptors.

Prednisolone is used for the same indications as all corticosteroids: rheumatism, polyarthritis, bronchial asthma, neurodermatitis, and eczema.

Safety

• Symbol(GHS): GHS08
• Signal word: Danger
• Hazard statements: H360FD
• Precautionary statements: P201-P202-P280-P308+P313-P405-P501
• Toxicity: LD50 oral in mouse: 1680mg/kg