A3479412
3,5-Diethoxycarbonyl-1,4-dihydro-2,4,6-collidine , >98.0%(GC) , 632-93-9
Synonym(s):
3,5-Dicarbethoxy-1,4-dihydrocollidine;DDC
CAS NO.：632-93-9
Empirical Formula: C14H21NO4
Molecular Weight: 267.32
MDL number: MFCD00005950
EINECS: 211-188-0
| Pack Size | Price | Stock | Quantity |
| 1G | RMB55.20 | In Stock |
|
| 5G | RMB107.20 | In Stock |
|
| 25G | RMB371.20 | In Stock |
|
| 100G | RMB1219.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 130-132 °C(lit.) |
| Boiling point: | 410.51°C (rough estimate) |
| Density | 1.1116 (rough estimate) |
| refractive index | 1.5280 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMF: 30 mg/ml; DMF:PBS (pH 7.2); (1:7): 0.125 mg/ml; DMSO: 20 mg/ml; Ethanol: 20 mg/ml |
| form | powder to crystal |
| pka | 3.53±0.70(Predicted) |
| color | White to Orange to Green |
Description and Uses
Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate (DDC) inhibits heme production by inhibiting ferrochelatase, the enzyme that catalyzes the addition of Fe2+ to protoporphyrin IX to create heme B. Chronic DDC administration induces Mallory-Denk body formation, a feature of alcoholic and non-alcoholic hepatitis, and reduces IL-12A methylation in mouse liver.
Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate was used to induce Mallory-Denk body formation in mice in vivo.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-37/39 |
| WGK Germany | 3 |
| RTECS | US7979375 |
| HS Code | 2933.39.9200 |
