Home Categories Pharmaceutical intermediates 3,5-Diethoxycarbonyl-1,4-dihydro-2,4,6-collidine
A3479412

3,5-Diethoxycarbonyl-1,4-dihydro-2,4,6-collidine , >98.0%(GC) , 632-93-9

Synonym(s):
3,5-Dicarbethoxy-1,4-dihydrocollidine;DDC

CAS NO.:632-93-9

Empirical Formula: C14H21NO4

Molecular Weight: 267.32

MDL number: MFCD00005950

EINECS: 211-188-0

Pack Size Price Stock Quantity
1G RMB55.20 In Stock
5G RMB107.20 In Stock
25G RMB371.20 In Stock
100G RMB1219.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 130-132 °C(lit.)
Boiling point: 410.51°C (rough estimate)
Density  1.1116 (rough estimate)
refractive index  1.5280 (estimate)
storage temp.  Keep in dark place,Sealed in dry,Room Temperature
solubility  DMF: 30 mg/ml; DMF:PBS (pH 7.2); (1:7): 0.125 mg/ml; DMSO: 20 mg/ml; Ethanol: 20 mg/ml
form  powder to crystal
pka 3.53±0.70(Predicted)
color  White to Orange to Green
CAS DataBase Reference 632-93-9(CAS DataBase Reference)
EPA Substance Registry System 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,4,6-trimethyl-, diethyl ester (632-93-9)

Description and Uses

Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate (DDC) inhibits heme production by inhibiting ferrochelatase, the enzyme that catalyzes the addition of Fe2+ to protoporphyrin IX to create heme B. Chronic DDC administration induces Mallory-Denk body formation, a feature of alcoholic and non-alcoholic hepatitis, and reduces IL-12A methylation in mouse liver.

Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate was used to induce Mallory-Denk body formation in mice in vivo.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-37/39
WGK Germany  3
RTECS  US7979375
HS Code  2933.39.9200

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