A3419512
Dorsomorphin , ≥98% , 866405-64-3
Synonym(s):
Compound C;Dorsomorphin, AMPK Inhibitor I, BMP Inhibitor I;InSolution ;6-(4-(2-Piperidin-1-yl-ethoxy)-phenyl)-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine, 2HCl, H?O, Compound C, 2HCl, H?O, AMPK Inhibitor I;6-[4-(2-Piperidin-1-yl-ethoxy)-phenyl)]-3-pyridin-4-yl-pyrrazolo[1,5-a]-pyrimidine, Dorsomorphin, BMP Inhibitor I, AMPK Inhibitor I
| Pack Size | Price | Stock | Quantity |
| 5MG | RMB375.20 | In Stock |
|
| 25MG | RMB1119.20 | In Stock |
|
| 100MG | RMB3092.00 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | >228°C(dec.) |
| Density | 1.25±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: >2mg/mL (warmed) |
| pka | 8.53±0.10(Predicted) |
| form | powder |
| color | white to beige |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
Description and Uses
Dorsomorphin (866405-64-3) is a potent, selective and ATP-competitive inhibitor of AMP-activated protein kinase (AMPK) (Ki = 109 nM).1 It displays no significant inhibition of ZAPK, SYK, PKCT, PKA and JAK3. It inhibits bone morphogenetic protein (BMP) type I receptors (ALK2, ALK3 and ALK6).2 Dorsomorphin has been shown to promote cardiomyogenesis in mouse embryonic stem cells (ESCs) in vitro.3 Dorsomorphin also induces autophagy in cancer cell lines via a mechanism independent of AMPK inhibition.4
A potent inhibitor of AMPK and fatty acid biosynthesis.
