Didanosine , ≥98%(HPLC) , 69655-05-6

Synonym(s):
2′,3′-Dideoxyinosine;ddI;ddIno

CAS NO.：69655-05-6

Empirical Formula: C10H12N4O3

Molecular Weight: 236.23

MDL number: MFCD00077728

EINECS: 614-994-4

PRODUCT Properties

• Melting point: 193-195 °C
• alpha: D25 -26.3° (c = 10 in water)
• Boiling point: 193-195 C
• Density: 1.2917 (rough estimate)
• refractive index: -28 ° (C=0.34, H2O)
• storage temp.: Inert atmosphere,Store in freezer, under -20°C
• solubility: Soluble in DMSO or methanol
• form: Powder
• pka: 9.12(at 25℃)
• color: White to Off-white
• Water Solubility: 1-5 g/100 mL at 21 ºC
• Merck: 14,3098
• BRN: 3619529
• BCS Class: 3
• Stability: Stable. Combustible. Incompatible with strong oxidizing agents.
• CAS DataBase Reference: 69655-05-6(CAS DataBase Reference)
• IARC: 3 (Vol. 76) 2000
• EPA Substance Registry System: Inosine, 2',3'-dideoxy- (69655-05-6)

Description and Uses

Didanosine is an orally active purine dideoxynucleoside analog indicated for adult and pediatric patients with advanced HIV infection who are either intolerant or significantly deteriorated on zidovudine. It appears to increase CD4 cell counts and decrease p24 antigen levels.Major adverse effects are pancreatitis, peripheral neuropathy and diarrhea.Unlike zidovudine, didanosine exhibits insignificant bone marrow suppression.

2?,3?-Dideoxyinosine is a potent anti-retroviral agent. It is most effective in combination therapy for the treatment of HIV and related lymphoma.

Safety

• Symbol(GHS): GHS08
• Signal word: Warning
• Hazard statements: H341-H373
• Precautionary statements: P201-P202-P260-P280-P308+P313-P405-P501
• Hazard Codes: C
• Risk Statements: 34-36/37
• Safety Statements: 26-27-36/37/39-45-24/25
• WGK Germany: 2
• RTECS: NM7460700
• HS Code: 29335990
• Hazardous Substances Data: 69655-05-6(Hazardous Substances Data)