Dipyridamole , ≥98% , 58-32-2

Synonym(s):
NSC 515776;NSC 619103

CAS NO.：58-32-2

Empirical Formula: C24H40N8O4

Molecular Weight: 504.63

MDL number: MFCD00010555

EINECS: 200-374-7

PRODUCT Properties

• Melting point: 165-166 °C (lit.)
• Boiling point: 593.96°C (rough estimate)
• Density: 1.2046 (rough estimate)
• refractive index: 1.6910 (estimate)
• storage temp.: room temp
• solubility: DMSO: soluble
• form: powder
• pka: pKa 6.4 (Uncertain)
• color: yellow
• Water Solubility: Soluble in chloroform, methanol, dilute acids, ethanol. Slightly soluble in water.
• Merck: 14,3346
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Description and Uses

Dipyridamole (58-32-2) is a phosphodiesterase inhibitor (IC50=0.37, 0.38, 0.45, 0.9 and 4.5 μM for PDE11, 6, 10, 5 and 8 respectively.1,2 Potent equilibrative nucleoside transporter 1 (ENT1) inhibitor Ki=8.2 nM vs. 144.8 nM for ENT1 and ENT2 respectively.3 Antiplatelet activity.4

A phosphodiester, cGMP, and non-specific nucleoside transport inhibitor

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P264-P271-P280-P302+P352-P305+P351+P338
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 2
• RTECS: KK7450000
• HS Code: 29335990
• Toxicity: LD50 in rats: 8.4 g/kg orally; 208 mg/kg i.v. (Takenaka)