Daunorubicin hydrochloride , >90% , 23541-50-6

Synonym(s):
Daunomycin hydrochloride;Daunomycin, HCl;Daunorubicin hydrochloride;Daunorubicin, Hydrochloride - CAS 23541-50-6 - Calbiochem

CAS NO.：23541-50-6

Empirical Formula: C27H30ClNO10

Molecular Weight: 563.98

MDL number: MFCD04974507

EINECS: 245-723-4

PRODUCT Properties

• Melting point: 190°C (dec)
• alpha: D20 +248 ±5° (c = 0.05-0.1 in methanol)
• storage temp.: Inert atmosphere,2-8°C
• solubility: Freely soluble in water and in methanol, slightly soluble in alcohol, practically insoluble in acetone.
• form: solid
• color: red to deep red
• Water Solubility: Soluble in water (50 mM)
• Sensitive: Hygroscopic
• λmax: 477nm(H2O)(lit.)
• Merck: 14,2832
• BRN: 4229221
• Stability: Stability
• InChIKey: GUGHGUXZJWAIAS-SMLRDAARNA-N
• SMILES: C1=CC2C(=O)C3=C(O)C4C[C@](C(C)=O)(O)C[C@H](O[C@@H]5O[C@@H](C)[C@@H](O)[C@@H](N)C5)C=4C(O)=C3C(=O)C=2C(OC)=C1.Cl |&1:10,16,18,20,22,24,r|
• EPA Substance Registry System: Daunorubicin hydrochloride (23541-50-6)

Description and Uses

Daunorubicin HCl (23541-50-6) is an antitumor antibiotic used in the treatment of acute myeloid leukemias.1?Induces DNA damage by intercalation.2?Induces apoptosis in a variety of cell lines.3?Inhibition of autophagy with chloroquine enhances daunorubicin-induced apoptosis in K562 cells.4?Cell permeable.

A DNA intercalator which may suppress acute leukemia proliferation

Safety

• Symbol(GHS): GHS06,GHS08
• Signal word: Danger
• Hazard statements: H301-H341-H351-H360FD
• Precautionary statements: P201-P202-P264-P270-P280-P301+P310
• Hazard Codes: Xn,Xi
• Risk Statements: 22-40-42/43-36/37/38-20/21/22
• Safety Statements: 22-36/37-45-37/39-36-26
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• RTECS: HB7878000
• F: 3-10
• HazardClass: 6.1(b)
• PackingGroup: III
• HS Code: 29419059
• Toxicity: LD50 in mice (mg/kg): 26 i.v. (DiMarco, 1969)