Doxofylline , 98% , 69975-86-6

CAS NO.：69975-86-6

Empirical Formula: C11H14N4O4

Molecular Weight: 266.25

MDL number: MFCD00865218

EINECS: 274-239-6

PRODUCT Properties

• Melting point: 144-146°C
• Boiling point: 409.46°C (rough estimate)
• Density: 1.2896 (rough estimate)
• refractive index: 1.6000 (estimate)
• RTECS: XH5135000
• storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
• solubility: DMSO (Slightly), Methanol (Slightly)
• form: Solid
• pka: 0.42±0.70(Predicted)
• color: White to Off-White
• Water Solubility: Soluble
• Merck: 14,3438
• InChI: InChI=1S/C11H14N4O4/c1-13-9-8(10(16)14(2)11(13)17)15(6-12-9)5-7-18-3-4-19-7/h6-7H,3-5H2,1-2H3
• InChIKey: HWXIGFIVGWUZAO-UHFFFAOYSA-N
• SMILES: N1(CC2OCCO2)C2=C(N(C)C(=O)N(C)C2=O)N=C1
• CAS DataBase Reference: 69975-86-6(CAS DataBase Reference)

Description and Uses

Doxofylline, a xanthine bronchodilator related to theophylline, is useful in the treatment of asthma and similar bronchospastic disorders. It has minimal activity on intestinal smooth muscle and the cardiovascular system, and is reportedly devoid of the behavioral effects of theophylline.

H1 antihistamine

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P264-P270-P301+P312+P330-P501-P301+P312a-P330-P501a
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36/37
• HS Code: 29399990
• Toxicity: LD50 in mice (mg/kg): 841 orally; 215.6 i.v.; in rats: 1022.4 orally, 445 i.p. (Franzone)