PRODUCT Properties
| Melting point: | 115° |
| alpha | D11 -139° in methanol |
| Boiling point: | 712.3±60.0 °C(Predicted) |
| Density | 1.185±0.06 g/cm3(Predicted) |
| storage temp. | -20°C Freezer, Under inert atmosphere |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 9.31±0.45(Predicted) |
| color | Pale Beige |
| Water Solubility | slightly soluble in water |
| InChIKey | AQASRZOCERRGBL-ROJLCIKYSA-N |
| SMILES | C1(O)=CC=C(C[C@@H]2C3=C(C=C(OC)C(OC)=C3)CCN2C)C=C1OC1=CC=C(C[C@@H]2C3=C(C=C(OC)C(OC)=C3)CCN2C)C=C1 |
Description and Uses
Dauricine is a kind of phenolic aromatic compound which is isolated from
Menispermaceae plants such as Asian Menispermum dauricum or Canadian
Menispermum dauricum and can be classified as isoquinoline alkaloids.
Rhizoma Menispermi is the dry rhizome of Menispermaceae plant Menispermum
dauricum. Menispermum dauricum mainly distributes in the northern part of East
Asia and is mainly distributed in the north, east and northeast regions of China. The
usage of Rhizoma Menispermi as a kind of traditional Chinese medicine was firstly
recorded in Kaibao Herbs with its function of detoxifying many drugs, relieving
pains, reducing swelling and sore, curing fever and cough, and killing parasites.
According to the Chinese Pharmacopoeia, Rhizoma Menispermi in the north of
China is different from the herbs used in the south of China known as the same
name. Based on the traditional Chinese Medicine theory, Rhizoma Menispermi has
the feature of bitterness and coldness, with the meridian tropism in the lung, stomach,
and intestine. The main effects of Rhizoma Menispermi are heat-clearing,
detoxicating, wind-dispelling and pain-relieving according to its vital function lies
in the therapy of swollen sore throat, enteritis diarrhea and rheumatic arthralgia.
Alkaloid is the main chemical component of Rhizoma Menispermi, and besides
dauricine, there are also other kinds of alkaloids such as dauriciline,
O-methyldauricine, and daurisoline in it.
Dauricine is a bisbenzylisoquinoline allkaloid derivative that displays a noted number of pharmaceutical properties. It is known to induces severe lung toxicity in animals.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 |
