1-Deoxymannojirimycin hydrochloride , 98% , 73465-43-7
Synonym(s):
1,5-Dideoxy-1,5-imino-D -mannitol hydrochloride
| Pack Size | Price | Stock | Quantity |
| 1MG | RMB227.20 | In Stock |
|
| 5MG | RMB532.80 | In Stock |
|
| 10MG | RMB936.00 | In Stock |
|
| 25MG | RMB1638.40 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 183-185°C |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | H2O: soluble10mg/mL |
| form | Powder |
| color | white to off-white |
| Water Solubility | Soluble in water (50 mM) |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 2 months. |
Description and Uses
1-Deoxymannojirimycin is a specific inhibitor of class I α-1,2-mannosidase (IC50 = 0.02 μM), a key enzyme for N-glycan processing in the endoplasmic reticulum and Golgi and for targeting misfolded proteins for translocation out of the endoplasmic reticulum and degradation by the proteasome. By inhibiting α-1,2-mannosidase activity, this compound generates N-linked oligosaccharides with high mannose content, preventing misfolded protein degradation. This compound has been used for studies on glycoprotein processing and as a model for the development of anticancer and antiviral therapies.
Deoxymannojirimycin has been shown to be a potent inhibitor of the mammalian Golgi alpha- mannosidase 1 activity, blocking the conversion of high-mannose oligosaccharides to complex-type oligosaccharides. However, it does not inhibit the biosynthesis of lipid- linked oligosaccharides.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302+H312+H332 |
| Precautionary statements | P261-P264-P280-P301+P312-P302+P352+P312-P304+P340+P312 |
| Hazard Codes | Xn,Xi |
| Risk Statements | 20/21/22-36/37/38 |
| Safety Statements | 22-24/25-36-37/39-26 |
| WGK Germany | 3 |
| HS Code | 2941900000 |
