Home Categories API Diosimin
A3207412

Diosimin , 95% , 520-27-4

Synonym(s):
3′,5,7-Trihydroxy-4′-methoxyflavone 7-rutinoside;Barosmin;Buchu resin;Diosmetin 7-O-rhamnosylglucoside;Diosmetin 7-rutinoside

CAS NO.:520-27-4

Empirical Formula: C28H32O15

Molecular Weight: 608.54

MDL number: MFCD00009772

EINECS: 208-289-7

Pack Size Price Stock Quantity
5G RMB48.80 In Stock
25G RMB124.00 In Stock
100G RMB380.00 In Stock
500g RMB1244.00 In Stock
others     Enquire
Update time: 2022-07-08

PRODUCT Properties

Melting point: 277-278°C
Boiling point: 926.8±65.0 °C(Predicted)
Density  1.68±0.1 g/cm3(Predicted)
vapor pressure  0Pa at 20℃
storage temp.  Sealed in dry,2-8°C
solubility  Practically insoluble in water, soluble in dimethyl sulfoxide, practically insoluble in alcohol. It dissolves in dilute solutions of alkali hydroxides.
form  Solid
pka 6.10±0.40(Predicted)
color  Pale Beige to Brown
Water Solubility  Soluble in DMSO (50 mg/ml), water (122 mg/ml at 25°C), and ethanol (<1 mg/ml at 25°C).
λmax 345nm(EtOH)(lit.)
Merck  14,3297
InChIKey GZSOSUNBTXMUFQ-YFAPSIMESA-N
LogP 0.14 at 20℃

Description and Uses

Diosmin was separated from the root of Scrophularia nodosa L. in 1925. The root of Scrophularia nodosa L. has the function of nourishing, reducing fever, relieving internal heat, and detoxicating. It was firstly recorded in the Shen Nong’s Classic of Materia Medica, as a class of middle-grade drug and is currently recorded in the Ch.P 2015, Volume I. The natural resource was abundant in China, mainly provided from Zhejiang, Sichuan, Hubei, Anhui, and Jiangsu provinces. In the clinical practice, Scrophularia nodosa L. was employed to eliminate pathogenic heat from the blood. In the clinical indication, diosmin was mainly applied to treat fever, polydipsia, maculitis, gingivitis, amygdalitis, laryngopharyngitis, acute lymphadenitis, etc. It also has the biological function of antiplatelet aggregation and antitumor. The chemical components include iridoids, phenylpropanoid glycoside, flavonoids, and fatty acids.

Diosmin is an agonist of the aryl hydrocarbon receptor (AhR) and exhibits anti-proliferative and anti-inflammatory. It is used in the treatment of venous disease, i.e., chronic venous insufficiency (CVI) and hemorrhoidal disease (HD). Diosmin also reduces capillary hyperpermeability and expression of endothelial adhesion molecules (ICAM1, VCAM1). It effectively inhibits the P-glycoprotein (Pgp)-mediated efflux in cells.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H412
Precautionary statements  P501-P273-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-36/37-24/25
WGK Germany  3
HS Code  29381000

RELATED PRODUCTS