Diosimin , Analysis standard , 520-27-4
Synonym(s):
3′,5,7-Trihydroxy-4′-methoxyflavone 7-rutinoside;Barosmin;Buchu resin;Diosmetin 7-O-rhamnosylglucoside;Diosmetin 7-rutinoside
CAS NO.：520-27-4
Empirical Formula: C28H32O15
Molecular Weight: 608.54
MDL number: MFCD00009772
EINECS: 208-289-7
| Pack Size | Price | Stock | Quantity |
| 20MG | RMB238.40 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 277-278°C |
| Boiling point: | 926.8±65.0 °C(Predicted) |
| Density | 1.68±0.1 g/cm3(Predicted) |
| vapor pressure | 0Pa at 20℃ |
| storage temp. | Sealed in dry,2-8°C |
| solubility | Practically insoluble in water, soluble in dimethyl sulfoxide, practically insoluble in alcohol. It dissolves in dilute solutions of alkali hydroxides. |
| form | Solid |
| pka | 6.10±0.40(Predicted) |
| color | Pale Beige to Brown |
| Water Solubility | Soluble in DMSO (50 mg/ml), water (122 mg/ml at 25°C), and ethanol (<1 mg/ml at 25°C). |
| λmax | 345nm(EtOH)(lit.) |
| Merck | 14,3297 |
| InChIKey | GZSOSUNBTXMUFQ-YFAPSIMESA-N |
| LogP | 0.14 at 20℃ |
Description and Uses
Diosmin was separated from the root of Scrophularia nodosa L. in 1925. The root of Scrophularia nodosa L. has the function of nourishing, reducing fever, relieving internal heat, and detoxicating. It was firstly recorded in the Shen Nong’s Classic of Materia Medica, as a class of middle-grade drug and is currently recorded in the Ch.P 2015, Volume I. The natural resource was abundant in China, mainly provided from Zhejiang, Sichuan, Hubei, Anhui, and Jiangsu provinces. In the clinical practice, Scrophularia nodosa L. was employed to eliminate pathogenic heat from the blood. In the clinical indication, diosmin was mainly applied to treat fever, polydipsia, maculitis, gingivitis, amygdalitis, laryngopharyngitis, acute lymphadenitis, etc. It also has the biological function of antiplatelet aggregation and antitumor. The chemical components include iridoids, phenylpropanoid glycoside, flavonoids, and fatty acids.
Diosmin is an agonist of the aryl hydrocarbon receptor (AhR) and exhibits anti-proliferative and anti-inflammatory. It is used in the treatment of venous disease, i.e., chronic venous insufficiency (CVI) and hemorrhoidal disease (HD). Diosmin also reduces capillary hyperpermeability and expression of endothelial adhesion molecules (ICAM1, VCAM1). It effectively inhibits the P-glycoprotein (Pgp)-mediated efflux in cells.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H412 |
| Precautionary statements | P501-P273-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36-36/37-24/25 |
| WGK Germany | 3 |
| HS Code | 29381000 |
