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A3194712

Neostigmine methyl sulfate , 98% , 51-60-5

Synonym(s):
3-(N,N-Dimethylcarbamoyloxy)-N,N,N,-trimethylanilinium methyl sulfate

CAS NO.:51-60-5

Empirical Formula: C12H19N2O2.CH3O4S

Molecular Weight: 334.39

MDL number: MFCD00011796

EINECS: 200-109-5

Pack Size Price Stock Quantity
1G RMB131.20 In Stock
5G RMB364.80 In Stock
25g RMB1399.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 175-177 °C(lit.)
storage temp.  -20°C
solubility  H2O: 1 g/mL
form  powder
color  white
Water Solubility  1g/10mL
Merck  14,6464

Description and Uses

Neostigmine is a reversible inhibitor of acetylcholinesterase (AChE; Kd = 260 μM). In a rat model of knee joint inflammation, intrathecal administration of neostigmine (2-30 μg) increases endogenous acetylcholine levels and dose-dependently increases the latency of paw withdrawal in response to thermal and mechanical stimuli (ED50s = 6.6 and 3.5 μg, respectively). Neostigmine (5 μg, i.p.) restores muscle action potentials in mice with a thymopoietin-induced neuromuscular block. Formulations containing neostigmine have been used in the treatment of myasthenia gravis and Ogilvie syndrome.

Cholinergic; miotic; antidote (curare)

Safety

Symbol(GHS) 
GHS06,GHS08
Signal word  Danger
Hazard statements  H300-H315-H319-H334-H335
Precautionary statements  P261-P284-P301+P330+P331+P310-P304+P340-P305+P351+P338-P342+P311
Hazard Codes  T+
Risk Statements  28-36/37/38-42/43-26/27/28
Safety Statements  36-45-36/37/39-28A
RIDADR  UN 2811 6.1/PG 2
WGK Germany  3
RTECS  CY1225000
HazardClass  6.1(a)
PackingGroup  II
HS Code  29242990
Toxicity LD50 in mice (mg/kg): 0.16 i.v.; 0.42 s.c.; 7.5 orally, (Randall, Lehmann)

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