Calcium dobesilate , 99% , 20123-80-2

CAS NO.：20123-80-2

Empirical Formula: 2C6H5O5S.Ca

Molecular Weight: 418.41

MDL number: MFCD00867249

EINECS: 243-531-5

PRODUCT Properties

• Melting point: >300° (dec)
• storage temp.: Inert atmosphere,Room Temperature
• solubility: H2O: soluble15mg/mL, clear
• form: powder
• color: white to beige
• Stability: Hygroscopic
• InChIKey: QGNBTYAQAPLTMX-UHFFFAOYSA-L

Description and Uses

Calcium dobesilate is a vasoprotective. It is the calcium salt of dobesilic acid. It is a synthetic molecule with the ability to reduce capillary permeability in the body. In Switzerland the drug is sold by the pharmaceutical company OM Pharma under the trade name of Doxium in capsules containing 500 mg of active ingredient.
Calcium dobesilate is indicated in states of fragility and altered capillary permeability, e.g. diabetic retinopathy, chronic venous disease and hemorrhoidal disease. In combination with lidocaine or with lidocaine and dexamethasone, the drug enters the composition of preparations for the therapy of hemorrhoidal disease. In association with potassium hydrodex-sulfate[citation needed] enters the composition of adjuvant gels in the treatment of varicose veins. The efficacy of calcium dobesilate has been described in patients with microangiopathies such as diabetic retinopathy and diabetic nephropathy.

Calcium dobesilate is an antioxidant that has been used to treat diabetic retinopathy, in which it slows progression of the disease during long-term oral treatment by reducing microvascular permeability, leading to improved visual acuity. It not only acts as an antioxidant but also stimulates endothelial production of nitric oxide.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P264-P271-P280-P302+P352-P305+P351+P338
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• HazardClass: IRRITANT
• Toxicity: LD50 in mice: 700 mg/kg (Esteve-Subirana)