6-chloro-3-nitropyridin-2-amine , 97% , 27048-04-0

CAS NO.：27048-04-0

Empirical Formula: C5H4ClN3O2

Molecular Weight: 173.56

MDL number: MFCD00044350

EINECS: 248-188-5

PRODUCT Properties

• Melting point: 195-196
• Boiling point: 339.9±37.0 °C(Predicted)
• Density: 1.596±0.06 g/cm3(Predicted)
• storage temp.: Keep in dark place,Inert atmosphere,2-8°C
• solubility: Chloroform, DMSO
• form: Crystalline
• pka: -1.69±0.50(Predicted)
• color: Yellow
• Water Solubility: Slightly soluble in water. Soluble in dimethyl sulfoxide and chloroform.
• InChI: InChI=1S/C5H4ClN3O2/c6-4-2-1-3(9(10)11)5(7)8-4/h1-2H,(H2,7,8)
• InChIKey: WERABQRUGJIMKQ-UHFFFAOYSA-N
• SMILES: C1(N)=NC(Cl)=CC=C1[N+]([O-])=O
• CAS DataBase Reference: 27048-04-0(CAS DataBase Reference)

Description and Uses

2-Amino-6-chloro-3-nitropyridine is a cytotoxic drug that has been shown to have anti-viral potency, as well as antiviral activity in an activity test. It is synthesized by reacting hydrogen tartrate with oxadiazole, and then hydrolyzing the resulting product with chloride. 2-Amino-6-chloro-3-nitropyridine has also been shown to inhibit human immunodeficiency virus type 1 (HIV) replication in vitro and to be effective against other viruses such as type 2 influenza. This drug can bind to the viral envelope and inhibit fusion of the viral membrane with host cells by preventing the release of viral contents into the cytoplasm. The binding affinity of 2-amino 6-chloro 3 nitropyridine for chloride may be due to hydrogen bonding interactions.

It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs.

Safety

• Symbol(GHS): GHS06
• Signal word: Warning
• Hazard statements: H302-H312-H315-H319-H331-H335
• Precautionary statements: P261-P280-P304+P340-P305+P351+P338-P405-P501a
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 22-26-36/37/39
• RIDADR: 2811
• Hazard Note: Irritant
• HazardClass: 6.1
• PackingGroup: Ⅲ
• HS Code: 29333999