Home Categories Organic Chemistry 2-Aminopyridine
A0635612

2-Aminopyridine , 99% , 504-29-0

Synonym(s):
o-Aminopyridine;2-Aminopyridine;2-AP;2-Pyridinamine;2-Pyridylamine

CAS NO.:504-29-0

Empirical Formula: C5H6N2

Molecular Weight: 94.11

MDL number: MFCD00006312

EINECS: 207-988-4

Update time: 2022-07-08

PRODUCT Properties

Melting point: 59 °C
Boiling point: 204-210 °C(lit.)
Density  1.0308 (estimate)
vapor pressure  5 hPa (125 °C)
refractive index  1.5560 (estimate)
Flash point: 198 °F
storage temp.  Store below +30°C.
solubility  890g/l
form  Crystalline Powder, Crystals or Flakes
pka 6.82(at 20℃)
color  Cream to light yellow-beige
Odor Characteristic odour
Water Solubility  Slightly soluble. 1-5 g/100 mL at 19 ºC
Sensitive  Hygroscopic
Merck  14,473
BRN  105785
Exposure limits NIOSH REL: TWA 0.5 ppm (2 mg/m3), IDLH 5 ppm; OSHA PEL: 0.5 ppm; ACGIH TLV: TWA 0.5 ppm.
LogP 0.53

Description and Uses

2-Aminopyridine is used primarily in the pharmaceutical industry as an intermediate in chemical synthesis. It is used to manufacturing analgesic and anti-inflammatory drugs piroxicam and lornoxicam. 2-Aminopyridine is a basic building block of several heterocyclic compounds and Schiff bases. It has been shown to reversibly block voltage-dependent potassium channels, and is also a common impurity from the synthesis of compounds found in hair dyes. It is a derivatizing agent which can be used as a fluorescent label for oligosaccharide detection, chromatographic separation, fluorometric or mass spectrometric analysis. 2AP and its derivatives are good candidates for antimicrobial, anticorrosion and molecular sensing applications.

Safety

Symbol(GHS) 
GHS05,GHS06
Signal word  Danger
Hazard statements  H301+H311-H314-H412
Precautionary statements  P260-P273-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338
Hazard Codes  T,Xi
Risk Statements  21-25-36/37/38-23/24/25
Safety Statements  26-36/37/39-45-38-28B
RIDADR  UN 2671 6.1/PG 2
OEB B
OEL TWA: 0.5 ppm (2 mg/m3)
WGK Germany  3
RTECS  US1575000
8-21
Autoignition Temperature >630 °C
Hazard Note  Toxic/Irritant
TSCA  Yes
HazardClass  6.1
PackingGroup  II
HS Code  29333999
Toxicity LD50 orally in Rabbit: 200 mg/kg
IDLA 5 ppm

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