Home Categories Chemical Reagents 3-Chloropropiophenone
A2637812

3-Chloropropiophenone , >96.0%(GC) , 936-59-4

Synonym(s):
β-Chloropropiophenone;3-Chloro-1-phenyl-1-propanone

CAS NO.:936-59-4

Empirical Formula: C9H9ClO

Molecular Weight: 168.62

MDL number: MFCD00000990

EINECS: 213-317-6

Pack Size Price Stock Quantity
5g RMB23.20 In Stock
25G RMB51.20 In Stock
100G RMB158.40 In Stock
500g RMB774.40 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 48-50 °C(lit.)
Boiling point: 113-115 °C4 mm Hg(lit.)
Density  1.1115 (rough estimate)
refractive index  1.5350 (estimate)
Flash point: >230 °F
storage temp.  Inert atmosphere,Room Temperature
solubility  Chloroform (Slightly), Methanol (Slightly)
form  Solid
color  Off-White to Pale Yellow
Water Solubility  Insoluble
BRN  2043580
Stability: Stable. Incompatible with strong bases, strong oxidizing agents.
CAS DataBase Reference 936-59-4(CAS DataBase Reference)
NIST Chemistry Reference 1-Propanone, 3-chloro-1-phenyl-(936-59-4)
EPA Substance Registry System 1-Propanone, 3-chloro-1-phenyl- (936-59-4)

Description and Uses

3-Chloropropiophenone is a chiral compound that is used as an antidepressant drug. It was first synthesized in the 1950s and has been studied extensively for its pharmacological effects. It is a racemic mixture of two enantiomers, one of which is active and the other inactive. The active enantiomer binds to serotonin receptors and inhibits the reuptake of serotonin, which leads to an increase in serotonin levels. The inactive enantiomer does not bind to serotonin receptors and does not inhibit the reuptake of serotonin. 3-Chloropropiophenone has been shown to be effective when administered at an optimum concentration of 5 milligrams per kilogram body weight.

3-Chloropropiophenone was used in the asymmetric reduction of (S)-3-chloro-1-phenylpropanol using preheated Candida utilis cells immobilized in calcium alginate gel beads. It was also used in the synthesis of (R)-3-chloro-1-phenyl-1-propanol via asymmetric reduction using in-situ generated oxazaborolidine catalyst derived from (S)-α,α-diphenylprolinol. It is a precursor of phenyl vinyl ketone.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P271-P280
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  37/39-26-24/25
WGK Germany  3
TSCA  Yes
HS Code  29147000

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