A2613251
RO20-1724 , ≥99% , 29925-17-5
Synonym(s):
4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone;Ro 20-1724;Ro-20-1724 - CAS 29925-17-5 - Calbiochem
Pack Size | Price | Stock | Quantity |
5mg | RMB127.20 | In Stock |
|
25mg | RMB399.20 | In Stock |
|
100mg | RMB1199.20 | In Stock |
|
others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
Boiling point: | 483.8±25.0 °C(Predicted) |
Density | 1.099±0.06 g/cm3(Predicted) |
storage temp. | room temp |
solubility | ethanol: 7 mg/mL |
form | solid |
pka | 14.54±0.40(Predicted) |
color | White |
Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 6 months. |
CAS DataBase Reference | 29925-17-5(CAS DataBase Reference) |
Description and Uses
RO 20-1724 (29925-17-5) is a selective inhibitor of cAMP-specific phosphodiesterase (PDE4), IC50 = 0.2 μM. Displays anti-inflammatory activity. Cell permeable
Ro 20-1724 is a cell-permeable, cAMP-specific phosphodiesterase type IV (PDE4) inhibitor (IC50 = 2 μM). It weakly inhibits PDE3 with a Ki value greater than 25 μM. Ro 20-1724 inhibits the release of cytokines and other inflammatory signals as well as prevents the development of reactive oxygen species. It is often used to study cAMP-related functions in vascular cells.
Safety
Symbol(GHS) | GHS07 |
Signal word | Warning |
Hazard statements | H335-H315-H319 |
Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 |
Hazard Codes | Xi |
Risk Statements | 36/37/38 |
Safety Statements | 26-36 |
WGK Germany | 3 |