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EHNAhydrochloride , ≥98% , 51350-19-7

Synonym(s):
erythro-9-(2-Hydroxy-3-nonyl)-adenine hydrochloride;erythro-9-(2-Hydroxy-3-nonyl)adenine, HCl;erythro-9-Amino-β-hexyl--α-methyl-9H-purine-9-ethanol hydrochloride;EHNA, Hydrochloride - CAS 51350-19-7 - Calbiochem

CAS NO.:51350-19-7

Empirical Formula: C14H23N5O

Molecular Weight: 277.37

MDL number: MFCD00151066

Pack Size Price Stock Quantity
10mg RMB1664.00 In Stock
50mg RMB6768.00 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 183~184℃
storage temp.  0-6°C
solubility  DMSO: 12 mg/mL
form  solid
color  white
Stability: Stable for 2 years as supplied. Solutions in distilled water may be stored at -20°C for up to 3 months.
CAS DataBase Reference 51350-19-7

Description and Uses

EHNA (51350-19-7) inhibits phosphodiesterase 2 (PDE2) (IC50 = 0.8 – 5.5 μM in a variety of tissues and species) over PDE1, PDE3, or PDE4 (IC50 values > 100 μM).1,2 It also inhibits adenosine deaminase (ADA), IC50 = 1.2 and 1.5 μM in human RBCs and astrocytoma cells, respectively3, which may be responsible for its ability to induce apoptosis in malignant pleural mesothelioma cell lines4. Because it blocks breakdown of adenosine to inosine and hypoxanthine, EHNA prevents formation of free radical substrates, protecting against cardiac reperfusion-mediated injury.5 It inhibits differentiation and maintains expression of pluripotency markers in hESCs, but not through inhibition of PDEs or ADA.6

A potent inhibitor of phosphodiesterase II (PDE II) (IC50=800nM). Does ot inhibit other PDE isozymes (IC50>100uM). Inhibits the retrograde transport motor, dynein. Also inhibits adenosine deaminase (Ki=4nM)

Safety

WGK Germany  3

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