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A2548312

Curcumin , ≥65% , 458-37-7

Synonym(s):
Curcumin;Diferuloylmethane;Diferulylmethane;Natural Yellow 3;(E,E)-1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione

CAS NO.:458-37-7

Empirical Formula: C21H20O6

Molecular Weight: 368.38

MDL number: MFCD01868798

EINECS: 207-280-5

Pack Size Price Stock Quantity
5G RMB22.40 In Stock
25G RMB41.60 In Stock
100G RMB127.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 183 °C
Boiling point: 418.73°C (rough estimate)
Density  0.93
vapor density  13 (vs air)
refractive index  1.4155-1.4175
Flash point: 208.9±23.6 °C
storage temp.  2-8°C
solubility  ethanol: 10 mg/mL
form  powder
Colour Index  75300
pka 8.09(at 25℃)
color  orange
Odor Odorless
PH Range Yellow (7.8) to red-brown (9.2)
Water Solubility  Slightly soluble (hot)
λmax 430nm
Merck  14,2673
Solvent Ethanol
Concentration 1 mCi/ml
Specific Activity 5-15 Ci/mmol
BRN  2306965
Stability: Stable, but may be light sensitive. Incompatible with strong oxidizing agents.
Major Application Cosmetics, drug-eluting stents, inhibition of formation of skin-wrinkles, treating alzheimer’s disease, skin diseases, coronary restenosis, diabetes, obesity, leukemia, neurofibromas, cancer, antimicrobial, antiviral, antiinflammatory, antiprostate cancer
InChIKey VFLDPWHFBUODDF-FCXRPNKRSA-N
LogP 3.290 (est)

Description and Uses

Curcumin is the major yellow pigment in turmeric and curry and has antioxidant, anti-inflammatory, and antitumor activities. It inhibits nitric oxide (NO) production (IC50 = 6 μM) and reduces inducible nitric oxide synthase (iNOS) activity in LPS-stimulated RAW 264.7 cells. Curcumin inhibits release of histamine and the inflammatory cytokines TNF-α, IL-1β, IL-6, and IL-8 from HMC-1 mast cells. In vivo, curcumin decreases serum levels of histamine and TNF-α, inhibits histopathological changes of nasal mucosa, and decreases the number of sneezes and nasal rubbing in a mouse model of ovalbumin-induced rhinitis. Curcumin (100 or 200 mg/kg) prevents ovalbumin-induced accumulation of 3-nitrotyrosine (3-NT), a marker of oxidative stress, in mouse heart. Topical administration of curcumin (1-10 μmol) reduces the number of tumors induced by phorbol 12-myristate 13-acetate (TPA; ) in mouse skin. Dietary administration of curcumin reduces the number of tongue neoplasms and preneoplastic lesions induced by 4-nitroquinoline 1-oxide (4-NQO) in rats.

antiedemic, antiinflammatory, bile stimulant; antibacterial, antifungal, lipo/cyclooxygenase inhibitor

Safety

Symbol(GHS) 
GHS02,GHS07
Signal word  Danger
Hazard statements  H225-H319
Precautionary statements  P210-P233-P240-P241-P242-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26
WGK Germany  3
RTECS  MI5230000
Hazard Note  Irritant
TSCA  Yes
HS Code  29145000
Toxicity LD50 Oral-Rat-12.200 mg/kg

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