Cytosine &#946;-<SC>D</SC>-arabinofuranoside hydrochloride , ≥99% , 69-74-9

Synonym(s):
Cytarabine;Arabinosylcytosine;Ara-C;Cytarabine hydrochloride;Cytosine arabinoside

CAS NO.：69-74-9

Empirical Formula: C9H14ClN3O5

Molecular Weight: 279.68

MDL number: MFCD00012839

EINECS: 200-713-9

PRODUCT Properties

• Melting point: 197-198 °C(lit.)
• storage temp.: 2-8°C
• solubility: insoluble in EtOH; ≥14.2 mg/mL in DMSO; ≥64.2 mg/mL in H2O
• form: crystalline
• color: White to off-white
• Stability: Stable. Combustible. Incompatible with strong oxidizing agents.
• InChI: InChI=1/C9H13N3O5.ClH/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8;/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16);1H/t4-,6-,7+,8-;/s3
• InChIKey: KCURWTAZOZXKSJ-XKIMMOKZSA-N
• SMILES: N1([C@@H]2O[C@H](CO)[C@@H](O)[C@@H]2O)C=CC(N)=NC1=O.[H]Cl |&1:1,3,6,8,r|

Description and Uses

Cytosine beta-D-arabinofuranoside Hydrochloride is the salt form of Cytarabine, which is a selective inhibitor of DNA synthesis and is used as an antineoplastic and antiviral. Cytosine beta-D-arabinofuranoside Hydrochloride is used in chemotherapy for the treatment of white blood cells cancers such as acute myeloid leukemia (AML) and non-Hodgkin lymphoma.

Antiviral.

Safety

• Symbol(GHS): GHS07,GHS08
• Signal word: Warning
• Hazard statements: H317-H319-H341-H361
• Precautionary statements: P201-P280-P302+P352-P305+P351+P338-P308+P313
• Hazard Codes: Xn
• Risk Statements: 36-43-63
• Safety Statements: 26-36/37
• WGK Germany: 3
• RTECS: HA5500000
• HazardClass: IRRITANT
• HS Code: 29389090
• Toxicity: LD50 oral in rat: > 3200mg/kg