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A5238712

Ketotifen Fumarate , 99% , 34580-14-8

Synonym(s):
Ketotifen fumarate salt

CAS NO.:34580-14-8

Empirical Formula: C23H23NO5S

Molecular Weight: 425.5

MDL number: MFCD00079394

EINECS: 252-100-0

Pack Size Price Stock Quantity
100mg RMB151.20 In Stock
250MG RMB191.20 In Stock
1G RMB327.20 In Stock
5G RMB1439.20 In Stock
25g RMB4799.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 192 C
storage temp.  2-8°C
solubility  Sparingly soluble in water, slightly soluble in methanol, very slightly soluble in acetonitrile.
form  Solid
color  White to Pale Beige
PH pH (10g/l, 25℃) : 3.0~4.0
Water Solubility  Soluble in water (10 mg/ml), DMSO (100 mM), and methanol.
λmax 297nm(MeOH)(lit.)
Merck  14,5307
InChIKey YNQQEYBLVYAWNX-WLHGVMLRSA-N
CAS DataBase Reference 34580-14-8(CAS DataBase Reference)

Description and Uses

Ketotifen is a histamine H1 receptor antagonist (Ki = 1.3 nM) and mast cell stabilizer. It is selective for H1 receptors over H2 and H3 receptors (Kis = 987 and 2,500 nM, respectively). Ketotifen (50 and 100 μM) inhibits degranulation of rat peritoneal mast cells induced by compound 48/80 . It inhibits the passive cutaneous anaphylaxis (PCA) reaction in rats by 54.6% when administered orally at a dose of 20 mg/kg. Ketotifen (30 mg/kg) inhibits the quick phase airway response in a rat ovalbumin-induced immediate airway response model. Formulations containing ketotifen have been used in the treatment of itching associated with allergic conjunctivitis.

Ketotifen fumarate salt has been used: for mast cell product antagonism, as a positive control in β-hexosaminidase release assay, as mast cell stabilizer to treat pregnant dams added to ad libitum drinking water

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H319
Precautionary statements  P264-P270-P280-P301+P312-P305+P351+P338-P337+P313
Hazard Codes  Xn,T
Risk Statements  22-36/37/38-23/24/25
Safety Statements  36-45-36/37/39-26
WGK Germany  3
RTECS  DE8260000
HS Code  29349990
Toxicity child,TDLo,oral,200ug/kg (0.2mg/kg),Drug Safety. Vol. 7, Pg. 387, 1992.

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