Calcium Ionophore A23187 , ≥97% , 52665-69-7

Synonym(s):
A23187, Free Acid, Streptomyces chartreusensis - CAS 52665-69-7 - Calbiochem;Antibiotic A 23187;Calcimycin;Calcium Ionophore A23187;Calimycin

CAS NO.：52665-69-7

Empirical Formula: C29H37N3O6

Molecular Weight: 523.62

MDL number: MFCD00151202

EINECS: 2580841

PRODUCT Properties

• Melting point: 187-190 °C
• alpha: D25 -56° (c = 1 in chloroform)
• Boiling point: 710.3±55.0 °C(Predicted)
• Density: 1.28±0.1 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: Soluble in DMSO with warming or sonication. Also soluble in ethanol or ethyl acetate
• form: Solid
• pka: pKa1 6.9 in 90% DMSO
• color: white to light yellow
• Merck: 13,1639
• BRN: 1096801
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 4 months.

Description and Uses

Antibiotic A-23187 (52665-69-7) is a highly selective divalent cation ionophore, commonly used to increase intracellular Ca2+ levels in intact cells (though it is most selective for Mn2+).1 It uncouples oxidative phosphorylation.2 In addition, antibiotic A-23187 inhibits ATPase activity.3

CA was used in elucidating the mechanisms underlying the positive and inotropic and chronotropic ability of CA on isolated superfused guinea pig atria. It may also be used to stimulate and measure the erythrocyte Ca²⁺ dependent K⁺ channels as the K⁺ efflux.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P280a-P304+P340-P305+P351+P338-P405-P501a
• Hazard Codes: Xi,Xn
• Risk Statements: 36/37/38-20/21/22
• Safety Statements: 26-36
• WGK Germany: 3
• RTECS: DM4676000
• F: 8
• HS Code: 29349990
• Toxicity: LD50 i.p. in mice: 10 mg/kg (Gale)