cholest-5-ene-3,25-diol , >99% , 2140-46-7
Synonym(s):
110816;5-Cholestene-3β,25-diol
| Pack Size | Price | Stock | Quantity |
| 5MG | RMB319.20 | In Stock |
|
| 10mg | RMB478.40 | In Stock |
|
| 25MG | RMB903.20 | In Stock |
|
| 50mg | RMB1615.20 | In Stock |
|
| 100MG | RMB2529.60 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 177-179 °C |
| Boiling point: | 513.1±23.0 °C(Predicted) |
| Density | 1.03±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | chloroform: 50 mg/mL, clear, colorless to slightly yellow |
| form | solid |
| pka | 15.03±0.70(Predicted) |
| color | White or pale yellow |
| Merck | 13,4846 |
| BRN | 3161259 |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| InChIKey | INBGSXNNRGWLJU-ZHHJOTBYSA-N |
| SMILES | [C@@]12([H])CC[C@H]([C@H](C)CCCC(O)(C)C)[C@@]1(C)CC[C@]1([H])[C@@]3(C)CC[C@H](O)CC3=CC[C@@]21[H] |&1:0,4,5,14,18,20,24,30,r| |
Description and Uses
25-hydroxy Cholesterol is an oxysterol. It is formed from cholesterol by cholesterol-25-hydroxylase, and its production can be induced by inflammation or infection. 25-hydroxy Cholesterol suppresses endogenous cholesterol synthesis by binding to insulin-induced gene (INSIG) proteins and preventing sterol regulatory element binding proteins (SREBPs) from being transported to the Golgi. It inhibits IgA class switching induced by LPS and various cytokines in B cells (IC50 = ~50 nM). 25-hydroxy Cholesterol inhibits replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Vero cells (EC50 = 3.675 μM) and reduces increases in viral protein production in infected Vero cells when used prior to infection. It reduces viral RNA loads in the lung and trachea in a mouse model of SARS-CoV-2 infection when administered at a dose of 100 mg/kg per day. Serum levels of 25-hydroxy cholesterol are increased in mice expressing human angiotensin-converting enzyme 2 (hACE2), the functional receptor for SARS-CoV-2, in a model of SARS-CoV-2 infection and in a patient with COVID-19, the primarily respiratory disease caused by SARS-CoV-2.
25-Hydroxycholesterol was used to treat mouse neuroblastoma cells to activate the ABCA1 signaling and in studies related to fatty acid metabolism.
Safety
| Symbol(GHS) |   GHS07,GHS08 |
| Signal word | Warning |
| Hazard statements | H302-H312-H315-H319-H332-H335-H373 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| Hazard Codes | Xn |
| Risk Statements | 20/21/22-36/37/38-48 |
| Safety Statements | 26-36-45 |
| WGK Germany | 3 |
| HS Code | 29062990 |
