Clozapine , ≥98% , 5786-21-0

Synonym(s):
8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]-diazepine;Clozapine

CAS NO.：5786-21-0

Empirical Formula: C18H19ClN4

Molecular Weight: 326.82

MDL number: MFCD00153785

EINECS: 227-313-7

PRODUCT Properties

• Melting point: 182-185°C
• Boiling point: 482.71°C (rough estimate)
• Density: 1.1327 (rough estimate)
• refractive index: 1.6110 (estimate)
• Flash point: 9℃
• storage temp.: 2-8°C
• solubility: ethanol: 1 mg/mL
• pka: 3.70, 7.60(at 25℃)
• form: powder
• color: pale yellow
• Merck: 14,2423
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
• CAS DataBase Reference: 5786-21-0(CAS DataBase Reference)
• NIST Chemistry Reference: Clozapine(5786-21-0)

Description and Uses

Clozapine (5786-21-0) is a dopamine D4?and D2?receptor antagonist. High affinity for the cloned rat dopamine D4?receptor (Ki?< 20 nM).1?Atypical neuroleptic agent.2?Antagonist at 5HT2A, 5HT2C, 5HT3, 5HT6 and 5HT7 receptors.3,4

depigmentor

Safety

• Symbol(GHS): GHS06,GHS08
• Signal word: Danger
• Hazard statements: H301-H341-H361
• Precautionary statements: P201-P202-P264-P270-P280-P301+P310
• Hazard Codes: Xn,Xi,T,F
• Risk Statements: 22-36/37/38-68-63-39/23/24/25-23/24/25-11
• Safety Statements: 26-36/37-45-16-7
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• RTECS: HP1750000
• HazardClass: 6.1(b)
• PackingGroup: III
• HS Code: 29339900
• Hazardous Substances Data: 5786-21-0(Hazardous Substances Data)
• Toxicity: LD50 in mice, rats (mg/kg): 61, 58 i.v.; 199, 260 orally (Lindt)