A2401112
Corticosterone , Analysis standard , 50-22-6
Synonym(s):
(11β)-11,21-Dihydroxypregn-4-ene-3,20-dione, Reichstein’s substance H;11β,21-Dihydroxy-4-pregnene-3,20-dione;11β,21-Dihydroxyprogesterone;4-Pregnene-11β,21-diol-3,20-dione;Corticosterone - CAS 50-22-6 - Calbiochem
CAS NO.：50-22-6
Empirical Formula: C21H30O4
Molecular Weight: 346.47
MDL number: MFCD00037715
EINECS: 200-019-6
| Pack Size | Price | Stock | Quantity |
| 100MG | RMB559.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 179-183 °C(lit.) |
| alpha | D15 +223° (c = 1.1 in alc) |
| Boiling point: | 401.19°C (rough estimate) |
| Density | 1.0413 (rough estimate) |
| refractive index | 1.4430 (estimate) |
| Flash point: | 9℃ |
| storage temp. | -20°C |
| solubility | Chloroform (Sparingly, Sonicated), Ethanol (Slightly, Sonicated) |
| form | White to tan crystalline powder |
| color | White to Pale Yellow |
| optical activity | [α]20/D +223±3°, c = 1% in ethanol |
| Water Solubility | 240.5mg/L(37 ºC) |
| Merck | 2538 |
| BRN | 2339601 |
| Stability: | Stable, but light sensitive. Incompatible with strong oxidizing agents. |
| CAS DataBase Reference | 50-22-6(CAS DataBase Reference) |
| EPA Substance Registry System | Corticosterone (50-22-6) |
Description and Uses
Corticosterone is a steroid hormone produced in the cortex of the adrenal glands that binds to both glucocorticoid and mineralocorticoid receptors. It is produced in response to ACTH (corticotropic hormone) and is the precursor to aldosterone synthesis. Since the production of glucocorticoids is increased by stress, it is often used as a biomarker of stress. Plasma corticosterone levels have a circadian variation and corticosterone may be important in the regulation of the sleep-
Corticosterone: HBC complex has been used:
- in the intravenous and intraperitoneal administration of corticosterone to rats to test its effect on glucocorticoid and mineralocorticoid activity
- to induce acute stress in mice
- in Pulsatile treatment in mice to test its effect on clock gene period 1 transcription
Safety
| Symbol(GHS) |   GHS07,GHS08 |
| Signal word | Warning |
| Hazard statements | H302+H312+H332-H351 |
| Precautionary statements | P202-P280-P301+P312-P302+P352+P312-P304+P340+P312-P308+P313 |
| Hazard Codes | Xi,N,Xn,T,F |
| Risk Statements | 43-40-39/23/24/25-23/24/25-11 |
| Safety Statements | 36-22-45-36/37-16 |
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |
| WGK Germany | 3 |
| RTECS | GM7650000 |
| HS Code | 29372900 |
| Toxicity | An adrenocortical steroid with modest glucocorticoid and mineralocorticoid activity. It is the primary glucocorticoid in the rat. |
