Carbenicillin disodium , USP level , 4800-94-6
Synonym(s):
α-Carboxybenzylpenicillin disodium salt;Carbenicillin disodium salt
CAS NO.：4800-94-6
Empirical Formula: C17H19N2NaO6S
Molecular Weight: 402.4
MDL number: MFCD00077683
EINECS: 225-360-8
| Pack Size | Price | Stock | Quantity |
| 1G | RMB60.00 | In Stock |
|
| 5G | RMB120.80 | In Stock |
|
| 10g | RMB227.20 | In Stock |
|
| 25G | RMB440.00 | In Stock |
|
| 100g | RMB1532.80 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | >190°C (dec.) |
| alpha | +175～+190°(D/20℃)(c=4,H2O)(calculated on the dehydrous basis) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | H2O: 50 mg/mL |
| form | powder |
| color | white to off-white |
| PH | 5.5～7.5 (10g/l, 25℃) |
| Water Solubility | Soluble in water. |
| Merck | 13,1801 |
| BRN | 5722128 |
Description and Uses
Carbenicillin is a broad-spectrum carboxypenicillin antibiotic. It is active against Gram-negative and certain Gram-positive bacteria, including S. pyogenes, S. epidermidis, P. mirabilis, P. vulgaris, E. coli, and P. aeruginosa (MICs = 0.19, 1.56, 1.56, 3.12, 3.12, and 50 μg/ml, respectively). It is also active against penicillinase-producing and non-producing strains of S. aureus (MICs = 1.56 and 12.5 μg/ml, respectively). Carbenicillin is protective against systemic S. pyogenes, P. vulgaris, E. coli, and S. aureus infection in a mouse model of systemic lethal infection with 50% protective dose (PD50) values of 7.8, 224, 19.3, and 34 mg/kg, respectively. It also decreases viable colony counts in the kidney in a rat model of P. vulgaris or E. coli urinary tract infection when administered at a dose of 100 mg/kg. Formulations containing carbenicillin have previously been used in the treatment of upper and lower urinary tract infections and prostatitis.
Carbenicillin disodium salt is a water-soluble antibiotic which is effective against gram-negative bacteria.Carbenicillin disodium salt is widely utilized as an antibiotic which is used to control bacterial cell-wall synthesis by inactivating transpeptidases on the inner surface of the bacterial cell membrane. It has been involved in the study of the role of penicillin-sensitive transpeptidases in cell wall biosynthesis.
Safety
| Symbol(GHS) |  GHS08 |
| Signal word | Danger |
| Hazard statements | H317-H334 |
| Precautionary statements | P261-P272-P280-P284-P302+P352-P333+P313 |
| Hazard Codes | Xn |
| Risk Statements | 42/43 |
| Safety Statements | 22-36/37-36 |
| RIDADR | UN 1170 3/PG 3 |
| WGK Germany | 2 |
| RTECS | ON9105000 |
| F | 3-8-10 |
| HS Code | 29411000 |
| Toxicity | LD50 i.p. in rats: >2000 mg/kg (Goldenthal) |
