15-Crown-5 , 97% , 33100-27-5

Synonym(s):
1,4,7,10,13-Pentaoxacyclopentadecane;15C5

CAS NO.：33100-27-5

Empirical Formula: C10H20O5

Molecular Weight: 220.26

MDL number: MFCD00005110

EINECS: 251-379-6

PRODUCT Properties

• Melting point: -20°C(lit.)
• Boiling point: 93-96 °C/0.05 mmHg (lit.)
• Density: 1.113 g/mL at 20 °C (lit.)
• vapor pressure: 0.5-0.82Pa at 20-25℃
• refractive index: n20/D 1.465(lit.)
• Flash point: >230 °F
• storage temp.: room temp
• solubility: Miscible with organic solvents.
• form: Liquid
• color: Clear colorless to light yellow
• Specific Gravity: 1.109
• Water Solubility: MISCIBLE
• Sensitive: Hygroscopic
• BRN: 1618144
• Stability: Stable. Incompatible with oxidizing agents, strong acids. Avoid exposure to water or moist air.
• LogP: -0.9 at 20℃ and pH7.7
• Surface tension: 68.5mN/m at 1g/L and 20℃

Description and Uses

15-Crown-5 is used as an efficient phase transfer catalyst and as a complexing agent. It is used to isolate oxonium ion (H7O3)+ salts especially from a solution of tetrchloroauric acid. It catalyzes the O-alkylation of the sodium salts of carboxylic acids in the penicillin and cephalosporin series, thereby facilitating esterification reaction without usage of acid. It is also used to facilitate the Williamson synthesis of ethers with hindered alcohols and sodium hydride. It is used with lithium aluminum hydride, for performing reduction reactions in hydrocarbon solvents. Further, it is involved in the Horner-Wadsworth-Emmons reaction to prepare stilbenes from aldehydes.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P301+P312+P330
• Hazard Codes: Xn,Xi
• Risk Statements: 22-36/38-36-20/22-36/37/38-20/21/22
• Safety Statements: 26-39-36
• RIDADR: 2810
• WGK Germany: 3
• RTECS: SB0200000
• F: 10-21
• Hazard Note: Irritant
• TSCA: Yes
• HazardClass: 6.1(b)
• PackingGroup: III
• HS Code: 29329995
• Toxicity: LD50 orl-rat: 1410 mg/kg DCTODJ 1,339,78