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A2258112

Crotaline , Analysis of standard products, ≥98% , 315-22-0

Synonym(s):
Crotaline;Monocrotaline

CAS NO.:315-22-0

Empirical Formula: C16H23NO6

Molecular Weight: 325.36

MDL number: MFCD00084656

EINECS: 628-506-2

Pack Size Price Stock Quantity
20MG RMB242.40 In Stock
50MG RMB943.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 204 °C (dec.) (lit.)
alpha  -54.8o (C=5 IN CHLOROFORM)
Boiling point: 463.55°C (rough estimate)
Density  1.1512 (rough estimate)
refractive index  1.5500 (estimate)
storage temp.  2-8°C
solubility  Soluble in DMSO (up to 50 mg/ml with warming), in Ethanol (up to 10 mg/ml with warming) or in organic solvents such as Chloroform (up to 50 mg/ml)
form  Solid
pka 12.21±0.60(Predicted)
color  White
Water Solubility  11.86g/L(temperature not stated)
Merck  13,6274
BRN  48732
Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
InChIKey QVCMHGGNRFRMAD-XFGHUUIASA-N
LogP -0.370 (est)

Description and Uses

A hepatotoxic alkaloid of the pyrrolizidine group obtained from Crotalaria retusa and C. spectabilis, the base is laevorotatory with [α]26D - 55.7° (CHCI3). It may be characterized as the hydrochloride, m.p. 184°C ldec.); [α]28D - 38.4° (H20) and the methiodide which crystallizes from MeOH with 3 moles of solvent, m.p. 205°C (dry, dec.); [α]28D + 23.4° (MeOH). Hydrolysis with boiling Ba(OHh furnishes retronecine and monocrotic acid, C7H120 3, b.p. 145-6°C/ 18 mm which is optically inactive. This acid yields a methyl ester, b.p. 94-6°Cj 18 mm, a p-bromophenacyl ester, m.p. 78°C and a 2:4-dinitrophenylhydrazone, m.p. 95-6°C. Hydrogenation in the presence of Pt02 as catalyst yields retro_x0002_necanol and monocrotalic acid, CSH120S' m.p. 181-2°C; [α]28D - 5.33° (H20) which gives a methyl ester, m.p. 79-800 C; [α]30D - 16.2° (EtOH) and a pbromophenacyl ester, m.p. 162-3°C.

antineoplastic, insect sterilant

Safety

Symbol(GHS) 
GHS06,GHS08
Signal word  Danger
Hazard statements  H301-H351
Precautionary statements  P201-P301+P310+P330
Hazard Codes  T
Risk Statements  25-40-35
Safety Statements  36/37/39-45
RIDADR  UN 1544 6.1/PG 3
WGK Germany  3
RTECS  QB3140000
HazardClass  6.1(b)
PackingGroup  III
HS Code  29399990
Toxicity LD50 orally in rats: 71 mg/kg (Newberne)

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