Arecoline hydrobromide , Analysis standard , 300-08-3
Synonym(s):
1-Methyl-1,2,5,6-tetrahydro-3-pyridinecarboxylic acid methyl ester hydrobromide;Arecaidine methyl ester hydrobromide;Methyl 1,2,5,6-tetrahydro-1-methyl-3-pyridinecarboxylate hydrobromide;Methyl 1-methyl-1,2,5,6-tetrahydronicotinate hydrobromide;Taeniolin
CAS NO.：300-08-3
Empirical Formula: C8H14BrNO2
Molecular Weight: 236.11
MDL number: MFCD00039041
EINECS: 206-087-3
| Pack Size | Price | Stock | Quantity |
| 50MG | RMB94.40 | In Stock |
|
| 250MG | RMB284.80 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 171-175 °C |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | H2O: 0.1 g/mL, clear, colorless |
| form | Powder |
| pka | 6.84(at 25℃) |
| color | White to light yellow |
| Merck | 14,778 |
| BRN | 3914826 |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions are not stable – make fresh daily. |
| InChI | InChI=1S/C8H13NO2.BrH/c1-9-5-3-4-7(6-9)8(10)11-2;/h4H,3,5-6H2,1-2H3;1H |
| InChIKey | AXOJRQLKMVSHHZ-UHFFFAOYSA-N |
| SMILES | C1(C(=O)OC)=CCCN(C)C1.Br |
Description and Uses
Arecoline (CAS 300-8-3) is a covalent inhibitor of ACAT1 which binds to and disrupts only ACAT1 tetramers (IC50=11.1 μM). ACAT2 and DLAT are not inhibited. Tyrosine407 phosphorylation activates mitochondrial acetyl-CoA acetyltransferase 1 (ACAT1) by stabilizing its tetramer. This is believed to be the mechanisms by which ACAT1 is “hijacked” and contributes to the Warburg effect in cancer.? Treatment of xenograft nude mice with Arecoline resulted in a dose-dependent reduction in tumor mass.1?Agonist at muscarinic acetylcholine receptors M1 – M5 (EC50?in the range of 7-410 nM).2?May be effective in dementia.3
Arecoline is a muscarinic acetylcholine receptor agonist. Arecoline induces ADP ribosylation of histones and chromatid relaxation in spleen and bone marrow cells. In a study, a controlled trial involving 122 dogs experimentally infected with Echinococcus
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P501 |
| Hazard Codes | Xn,T |
| Risk Statements | 22-23/24/25 |
| Safety Statements | 45-38-36/37/39-28A |
| RIDADR | 1544 |
| WGK Germany | 3 |
| RTECS | QT2275000 |
| F | 8 |
| HazardClass | 6.1 |
| PackingGroup | III |
| HS Code | 29399990 |
| Toxicity | LD50 par-rat: 270 mg/kg ABMGAJ 28,681,72 |
