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A2136056

JZL184

Synonym(s):
4-Nitrophenyl-4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate, Monoacylglycerol Lipase Inhibitor III, JZL184;MAGL Inhibitor III, JZL184 - CAS 1101854-58-3 - Calbiochem

CAS NO.:

Empirical Formula: C27H24N2O9

Molecular Weight: 520.49

MDL number:

Pack Size Price Stock Quantity
5mg RMB661.60 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 116-120°C
Boiling point: 706.4±60.0 °C(Predicted)
Density  1.467±0.06 g/cm3(Predicted)
storage temp.  2-8°C
solubility  Soluble in DMSO (up to 25 mg/ml).
form  White to off-white solid
pka 13.32±0.29(Predicted)
color  light yellow to yellow-green
Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months

Description and Uses

Endocannabinoids such as 2-arachidonoyl glycerol (2-AG) and arachidonoyl ethanolamide (AEA) are biologically active lipids that are involved in a number of synaptic processes including activation of cannabinoid receptors. Monoacylglycerol lipase (MAGL) is a serine hydrolase responsible for the hydrolysis of 2-AG to arachidonic acid and glycerol, thus terminating its biological function. JZL 184 is a potent and selective inhibitor of monoacylglycerol lipase (MAGL) that displays IC50 values of 8 nM and 4 μM for inhibition of MAGL and fatty acid amide hydrolase in mouse brain membranes, respectively. When administered to mice at 16 mg/kg, intraperitoneally, JZL 184 reduces MAGL activity by 85%, elevates brain 2-AG levels by 8-fold, and elicits analgesic activity in a variety of pain assays that qualitatively mimics direct central cannabinoid (CB1) agonists.

JZL184 is a strong and selective inhibitor of Monoglyceride Lipase.

Safety

Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P301+P310
RIDADR  UN 2811 6.1 / PGIII
HS Code  29349990

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