URB597 , ≥98% , 546141-08-6

Synonym(s):
Cyclohexylcarbamic acid 3′-carbamoyl-biphenyl-3-yl ester;FAAH Inhibitor II - CAS 546141-08-6 - Calbiochem;URB597, Cyclohexylcarbamic acid-3ʹ-carbamoyl-biphenyl-3-yl Ester, 3ʹ-Carbamoyl-biphenyl-3-yl-cyclohexylcarbamate

CAS NO.：546141-08-6

Empirical Formula: C20H22N2O3

Molecular Weight: 338.4

MDL number: MFCD05863934

EINECS: 637-274-1

PRODUCT Properties

• Boiling point: 533.2±50.0 °C(Predicted)
• Density: 1.23
• storage temp.: 2-8°C
• solubility: DMSO: ~14 mg/mL, soluble
• form: powder
• pka: 11.74±0.20(Predicted)
• color: white
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

Description and Uses

URB-597 (546141-08-6) is a potent and selective fatty acid amide hydrolase (FAAH) inhibitor, IC50 = 3-5 nM.1?Produces cannabinoid CB1 and CB2 receptor-mediated analgesia in inflammatory pain states without causing side effects associated with cannabinoid receptor activation.2?Attenuates the anxiolytic-like effect of acetaminophen in a mouse model.3?Exerts anti-inflammatory effects in rat hippocampus and ameliorates age-related deficits.4?Off target effects of URB-597: Reduces tyrosine hydroxylase expression.5 Improves cognitive?impairment caused by chronic cerebral hypoperfusion in a mouse model via inhibition of mTOR-dependent autophagy.6

URB597 is a potent, selective fatty acid amide hydrolase (FAAH) inhibitor.

Safety

• Symbol(GHS): GHS07,GHS09
• Signal word: Warning
• Hazard statements: H319-H410
• Precautionary statements: P273-P305+P351+P338-P501
• Hazard Codes: N
• Risk Statements: 50/53
• Safety Statements: 22-24/25-60-61
• RIDADR: UN 3077 9/PG 3
• WGK Germany: 3