Kifunensine , 98% , 109944-15-2
Synonym(s):
FR 900494;Hexahydro-6R,7S,8aS-trihydroxy-5R-(hydroxymethyl)-imidazo[1,2-a] pyridine-2,3-dione;Kifunensine, Kitasatosporia kifunense - CAS 109944-15-2 - Calbiochem
| Pack Size | Price | Stock | Quantity |
| 1mg | RMB600.00 | In Stock |
|
| 5mg | RMB2159.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | >280°C |
| Density | 1.85±0.1 g/cm3(Predicted) |
| storage temp. | −20°C |
| solubility | water, double-distilled: soluble50MM |
| form | White solid |
| pka | 9.61±0.70(Predicted) |
| color | White |
| Water Solubility | Soluble to 5 mM in water with sonication |
| Stability: | Desiccate and Store at -20°C |
Description and Uses
Historically isolated from Kitasatosporia kifunense.1?Kifunensine (CAS 109944-15-2) is an inhibitor of class I α-mannosidases which inhibit glycoprotein processing. Inhibits human endoplasmic reticulum α-1,2-mannosidase I and Golgi Class I mannosidases IA, IB and IC with Ki values of 130 and 23 nM respectively.2 Inhibition of endoplasmic reticulum a-mannosidase I activity rescues the human a-sarcoglycan R77C mutation suggesting a new pharmacological approach for limb girdle muscular dystrophy type 2D patients carrying mutations that impair a-sarcoglycan trafficking.3 Improves maturation of misfolded proteins.4
Kifunensine is an alkaloid produced by the fungus, Kitasatosporia kifunense, and has been shown to be a weak inhibitor of aryl mannosidase. It is a unique oxamide derivative of mannojirimycin and a potent inhibitor of the glycoprotein processing enzyme mannosidase I. Kifunenesine is ineffective in inhibiting either mannosidase II or the endoplasmic reticulum (ER) a-mannosidase. It also possesses immunomodulating properties based on chemical, physicochemical and x-ray crystallographic analysis.When tested in cell culture using influenza virus-infected MDCK cells, kifunensine, at 1 mg/ml or less, caused almost complete inhibition of complex chain formation with the accumulation of Man9(GlcNAc)2. Thus, kifunensine was proven to be 50 to 100 times more effective than deoxymannojirimycin.Ph
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H319 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313 |
| WGK Germany | 3 |
| HS Code | 2939800000 |
