≥97%

Synonym(s):
DTT;1,4-Dithiothreitol;Cleland’s reagent;Dithiothreitol, DTT;(±)-threo-1,4-Dimercapto-2,3-butanediol solution

CAS NO.：

Empirical Formula: C4H10O2S2

Molecular Weight: 154.25

MDL number: MFCD00004877

EINECS: 222-468-7

PRODUCT Properties

• Melting point: 41-44 °C(lit.)
• Boiling point: 125 °C
• alpha: -0.2～+0.2°(20℃/D)(c=5,H2O)
• Density: 1.04 g/mL at 20 °C
• vapor density: 5.3 (vs air)
• vapor pressure: 0.019-0.29Pa at 20-50℃
• refractive index: 1.5200 (estimate)
• Flash point: >230 °F
• storage temp.: -20°C (or 4°C short term).
• solubility: H₂O: 50 mg/mL, clear, colorless
• pka: pK1:8.9 (25°C)
• form: Powder
• color: White
• PH: 4.0-6.0 (20-25℃, 0.1m in H2O)
• Odor: Unpleasant Odor
• PH Range: 4 - 6 at 15,4 g/l at 25 °C
• Water Solubility: freely soluble
• λmax: λ: 260 nm Amax: 0.400; λ: 280 nm Amax: 0.100
• Sensitive: Air Sensitive
• Merck: 14,3376
• BRN: 1719757
• Stability: Stability Stable, but heat sensitive. Incompatible with strong oxidizing agents. Keep frozen at -20 to -10 C.
• InChIKey: VHJLVAABSRFDPM-UHFFFAOYSA-N
• LogP: 0.07 at 25℃ and pH5
• CAS DataBase Reference: 3483-12-3(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-Butanediol, 1,4-dimercapto-, (r*,r*)-(3483-12-3)
• EPA Substance Registry System: 1,4-Dithiothreitol (3483-12-3)

Description and Uses

Dithiothreitol is a redox reagent commonly used as a reducing agent for thiolated DNA. Dithiothreitol is also used to reduce the disulfide bonds of proteins.

Safety

• Symbol(GHS): GHS05,GHS07
• Signal word: Danger
• Hazard statements: H302-H315-H318
• Precautionary statements: P264-P270-P280-P301+P312-P302+P352-P305+P351+P338
• Hazard Codes: Xn
• Risk Statements: 25-36/37/38-22-20/21/22
• Safety Statements: 26-45-37/39-36
• RIDADR: UN 3335
• WGK Germany: 3
• RTECS: EK1610000
• F: 3-10-16-23
• TSCA: Yes
• HS Code: 29309099
• Hazardous Substances Data: 3483-12-3(Hazardous Substances Data)