A1503512
2-Bromo-4'-hydroxyacetophenone , >98.0%(HPLC) , 2491-38-5
Synonym(s):
p-Hydroxyphenacyl bromide;2-Bromo-1-(4-hydroxyphenyl)ethanone;Protein Tyrosine Phosphatase Inhibitor I, α-Bromo-4-hydroxyacetophenone, 4-Hydroxyphenacyl Br, SHP1 Inhibitor II;PTP Inhibitor I - CAS 2491-38-5 - Calbiochem
CAS NO.：2491-38-5
Empirical Formula: C8H7BrO2
Molecular Weight: 215.04
MDL number: MFCD00072424
EINECS: 219-655-0
| Pack Size | Price | Stock | Quantity |
| 5G | RMB23.20 | In Stock |
|
| 25G | RMB95.20 | In Stock |
|
| 100G | RMB332.00 | In Stock |
|
| 500g | RMB1519.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 123-126°C |
| Boiling point: | 338.7±17.0 °C(Predicted) |
| Density | 1.622±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | 7.69±0.15(Predicted) |
| form | White powder |
| color | White to Light Beige |
| Sensitive | Lachrymatory |
| BRN | 1865388 |
| Stability: | Hygroscopic |
Description and Uses
PTP Inhibitor I is a cell-permeable, protein tyrosine phosphatase (PTP) inhibitor that covalently blocks the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)) with a Ki value of 43 μM and PTP1B with a Ki value of 42 μM. SHP-1 and PTP1B both have known roles in regulating insulin signaling as well as myeloid and lymphoid cell differentiation, making inhibitors of these phosphatases of interest in diabetes, cancer, allergy, and inflammation research.
A covalent inhibitor of protein tyrosine phosphatases (PTPs)
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H319 |
| Precautionary statements | P264-P270-P280-P301+P312-P305+P351+P338-P337+P313 |
| Hazard Codes | C,Xn |
| Risk Statements | 22-36 |
| Safety Statements | 26 |
| RIDADR | 1760 |
| WGK Germany | 1 |
| RTECS | AM5982000 |
| Hazard Note | Corrosive/Lachrymatory/Keep Cold |
| HazardClass | 8 |
| PackingGroup | III |
| HS Code | 2914500090 |
