Home Categories 2-Bromo-4'-hydroxyacetophenone
A1503512

2-Bromo-4'-hydroxyacetophenone , >98.0%(HPLC) , 2491-38-5

Synonym(s):
p-Hydroxyphenacyl bromide;2-Bromo-1-(4-hydroxyphenyl)ethanone;Protein Tyrosine Phosphatase Inhibitor I, α-Bromo-4-hydroxyacetophenone, 4-Hydroxyphenacyl Br, SHP1 Inhibitor II;PTP Inhibitor I - CAS 2491-38-5 - Calbiochem

CAS NO.:2491-38-5

Empirical Formula: C8H7BrO2

Molecular Weight: 215.04

MDL number: MFCD00072424

EINECS: 219-655-0

Pack Size Price Stock Quantity
5G RMB23.20 In Stock
25G RMB95.20 In Stock
100G RMB332.00 In Stock
500g RMB1519.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 123-126°C
Boiling point: 338.7±17.0 °C(Predicted)
Density  1.622±0.06 g/cm3(Predicted)
storage temp.  Inert atmosphere,2-8°C
solubility  Chloroform (Slightly), Methanol (Slightly)
pka 7.69±0.15(Predicted)
form  White powder
color  White to Light Beige
Sensitive  Lachrymatory
BRN  1865388
Stability: Hygroscopic
CAS DataBase Reference 2491-38-5(CAS DataBase Reference)
EPA Substance Registry System 2-Bromo-4-hydroxyacetophenone (2491-38-5)

Description and Uses

PTP Inhibitor I is a cell-permeable, protein tyrosine phosphatase (PTP) inhibitor that covalently blocks the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)) with a Ki value of 43 μM and PTP1B with a Ki value of 42 μM. SHP-1 and PTP1B both have known roles in regulating insulin signaling as well as myeloid and lymphoid cell differentiation, making inhibitors of these phosphatases of interest in diabetes, cancer, allergy, and inflammation research.

A covalent inhibitor of protein tyrosine phosphatases (PTPs)

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H319
Precautionary statements  P264-P270-P280-P301+P312-P305+P351+P338-P337+P313
Hazard Codes  C,Xn
Risk Statements  22-36
Safety Statements  26
RIDADR  1760
WGK Germany  1
RTECS  AM5982000
Hazard Note  Corrosive/Lachrymatory/Keep Cold
HazardClass  8
PackingGroup  III
HS Code  2914500090

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