2，3-Bis(4-hydroxyphenyl)propionitrile , ≥98%(HPLC) , 1428-67-7
Synonym(s):
Diarylpropionitrile;DPN;SC-4473
| Pack Size | Price | Stock | Quantity |
| 10MG | RMB434.40 | In Stock |
|
| 50MG | RMB1512.00 | In Stock |
|
| 250mg | RMB4784.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 200.0 to 204.0 °C |
| Boiling point: | 449.4±35.0 °C(Predicted) |
| Density | 1.256±0.06 g/cm3(Predicted) |
| RTECS | UG0900000 |
| storage temp. | -20°C |
| solubility | DMSO: soluble10mg/mL, clear |
| form | powder |
| pka | 9.41±0.26(Predicted) |
| color | white to beige |
| Water Solubility | Soluble in 1eq. NaOH (30 mM), ethanol (100 mM), DMSO (100 mM), DMF (~30 mg/ml), and water (0.5 mg/ml at 25°C). |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
Description and Uses
DPN (1428-67-7) is a potent estrogen ERβ receptor agonist. Displays a 70-fold selectivity over ERα, EC50 = 0.85 and 66 nM, respectively.1 Regulates expression of GluR1, 2 and 3 in rat hippocampus.2 Ameliorates portal hypertension in a carbon tetrachloride-induced liver cirrhosis rat model.3 Stimulates proliferation of androgen-independent prostate cancer cell line PC-3 via a novel pathway involving ERβ-mediated activation of β-catenin.4 A useful tool for elucidating the biological function of ERβ.5
2,3-Bis(4-hydroxyphenyl)propionitrile is an estrogen receptor β and α specific with pro- and anti-nociceptive actions in mice.
Safety
| Symbol(GHS) |   GHS07,GHS09 |
| Signal word | Warning |
| Hazard statements | H319-H400 |
| Precautionary statements | P273-P305+P351+P338 |
| Hazard Codes | Xi,N |
| Risk Statements | 36-50 |
| Safety Statements | 26-61 |
| RIDADR | UN 3077 9 / PGIII |
| WGK Germany | 3 |
| HS Code | 2926.90.4801 |
| HazardClass | 9 |
