BIBR 1532 , ≥98% , 321674-73-1
Synonym(s):
BIBR 1532, BIBR-1532;Telomerase Inhibitor X, BIBR1532 - CAS 321674-73-1 - Calbiochem
| Pack Size | Price | Stock | Quantity |
| 10MG | RMB446.40 | In Stock |
|
| 50MG | RMB2399.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | >173oC (dec.) |
| Boiling point: | 600.6±48.0 °C(Predicted) |
| Density | 1.284 |
| storage temp. | Store at RT |
| solubility | DMSO (Slightly), Methanol (Slightly, Sonicated) |
| form | Solid |
| pka | 3.46±0.36(Predicted) |
| color | White to Off-White |
Description and Uses
BIBR 1532 is a mixed-type non-competitive inhibitor of telomerase (IC50 = 93 nM) that has little effect on several mammalian DNA and RNA polymerases, bacterial DNA helicase, or HIV-1 reverse transcriptase. It specifically targets the telomerase reverse transcriptase catalytic subunit, TERT. Through its effects on telomerase, BIBR 1532 induces senescence or apoptosis in cancer cells. Apoptosis in triple negative breast cancer cells induced by BIBR 1532 is potentiated by glucose restriction.
BIBR 1532 is a mixed-type non-competitive inhibitor of telomerase. It specifically targets the telomerase reverse transcriptase catalytic subunit, TERT.
