Bardoxolone Methyl , ≥98% , 218600-53-4
CAS NO.:218600-53-4
Empirical Formula: C32H43NO4
Molecular Weight: 505.69
MDL number: MFCD11983137
EINECS: 606-850-4
Pack Size | Price | Stock | Quantity |
25MG | RMB551.20 | In Stock |
|
100MG | RMB1759.20 | In Stock |
|
others | Enquire |
PRODUCT Properties
Melting point: | 215-223°C |
Boiling point: | 600.8±55.0 °C(Predicted) |
Density | 1.15 |
storage temp. | Refrigerator |
solubility | Chloroform (Slightly), Methanol (Slightly) |
form | Solid |
color | White to Light Brown |
InChIKey | WPTTVJLTNAWYAO-KPOXMGGZSA-N |
SMILES | C1(=O)[C@@]([C@]2([C@](C)(C=C1C#N)C1[C@@]([C@]3([C@@](C(=O)C=1)([H])[C@]1([C@@](CC[C@](C1)(C)C)(C(OC)=O)CC3)[H])C)(C)CC2)[H])(C)C |
CAS DataBase Reference | 218600-53-4 |
Description and Uses
Bardoxolone methyl is an antioxidant inflammatory modulator that reversibly interacts with critical free thiol groups of cysteine residues on KEAP-1 and other target proteins, inducing the trans-location of Nrf-2 to the nucleus and the activation of several genes, including glutathione S-transferase, haeme oxygenase, and other components of the cytoprotective response (Thomas et al., 2012). At high doses, bardoxolone methyl may also interact with other proteins, including PPAR-gamma, tubulin, and the kinase activa-tor IKK.
CDDO Methyl Ester is a synthetic triterpenoid that inhibits IκBα kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor κB-regulated gene products in human leukemic cells. CDDO Methyl Ester is a novel therapeutic agent in the treatment of acute myeloid leukemia and in the treatment of pancreatic cancer as well as other forms of cancer.
Safety
Symbol(GHS) | GHS08 |
Signal word | Warning |
Hazard statements | H371 |
Precautionary statements | P260-P264-P270-P309+P311-P405-P501 |