Home Categories Biochemical Engineering Bardoxolone Methyl
A1415312

Bardoxolone Methyl , ≥98% , 218600-53-4

CAS NO.:218600-53-4

Empirical Formula: C32H43NO4

Molecular Weight: 505.69

MDL number: MFCD11983137

EINECS: 606-850-4

Pack Size Price Stock Quantity
25MG RMB551.20 In Stock
100MG RMB1759.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 215-223°C
Boiling point: 600.8±55.0 °C(Predicted)
Density  1.15
storage temp.  Refrigerator
solubility  Chloroform (Slightly), Methanol (Slightly)
form  Solid
color  White to Light Brown
InChIKey WPTTVJLTNAWYAO-KPOXMGGZSA-N
SMILES C1(=O)[C@@]([C@]2([C@](C)(C=C1C#N)C1[C@@]([C@]3([C@@](C(=O)C=1)([H])[C@]1([C@@](CC[C@](C1)(C)C)(C(OC)=O)CC3)[H])C)(C)CC2)[H])(C)C

Description and Uses

Bardoxolone methyl is an antioxidant inflammatory modulator that reversibly interacts with critical free thiol groups of cysteine residues on KEAP-1 and other target proteins, inducing the trans-location of Nrf-2 to the nucleus and the activation of several genes, including glutathione S-transferase, haeme oxygenase, and other components of the cytoprotective response (Thomas et al., 2012). At high doses, bardoxolone methyl may also interact with other proteins, including PPAR-gamma, tubulin, and the kinase activa-tor IKK.

CDDO Methyl Ester is a synthetic triterpenoid that inhibits IκBα kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor κB-regulated gene products in human leukemic cells. CDDO Methyl Ester is a novel therapeutic agent in the treatment of acute myeloid leukemia and in the treatment of pancreatic cancer as well as other forms of cancer.

Safety

Symbol(GHS) 
GHS08
Signal word  Warning
Hazard statements  H371
Precautionary statements  P260-P264-P270-P309+P311-P405-P501

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