Balofloxacin , 98% , 127294-70-6

Synonym(s):
(±)-1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[3-(methylamino)piperidino]-4-oxo-3-quinolinecarboxylic acid

CAS NO.：127294-70-6

Empirical Formula: C20H24FN3O4

Molecular Weight: 389.42

MDL number: MFCD00864925

EINECS: 1312995-182-4

PRODUCT Properties

• Melting point: 137°C
• Boiling point: 608.3±55.0 °C(Predicted)
• Density: 1.40±0.1 g/cm3(Predicted)
• storage temp.: Keep in dark place,Inert atmosphere,2-8°C
• solubility: H2O : < 0.1 mg/mL (insoluble)DMSO : 0.67 mg/mL (1.72 mM; Need ultrasonic)
• form: Solid
• pka: 6.44±0.50(Predicted)
• color: White to off-white
• BRN: 8362117
• CAS DataBase Reference: 127294-70-6(CAS DataBase Reference)

Description and Uses

Balofloxacin, a novel orally-active fluoroquinolone antibiotic, was introduced in South Korea for the treatment of urinary tract infections (UTI). It can be synthetized by reaction of 3-(methylamino)piperidine with the classical 4-quinolone-3-carboxylic acid template. In vitro antibacterial activity of balofloxacin against gram-positive bacteria (Staphylococcus aureus including methicillin-resistant S. aureus, Staphylococcus epidermis, Streptococcus pneumonia, Streptococcus pyrogenes) was almost equal to that of sparfloxacin or tosufloxacin, in contrast its activity against gram-negative bacteria was 2 times or more lower. In clinical trials, balofloxacin was well tolerated and showed comparable efficacy to ofloxacin in patients with UTls. After oral administration, balofloxacin was well absorbed, and was primarily eliminated unchanged in the urine with an elimination half-life of approximately 8 h. In animal studies, balofloxacin did not exhibit any phototoxicity.

Fluorinated quinolone antibacterial.

Safety

• Symbol(GHS): GHS02
• Signal word: Warning
• Hazard statements: H228
• Precautionary statements: P403-P501c
• WGK Germany: 3