Butoconazole nitrate , ≥99% , 64872-77-1

Synonym(s):
Butoconazole nitrate;Gynazole-1;Gynomyk;Exelgyn;Femstat One

CAS NO.：64872-77-1

Empirical Formula: C19H18Cl3N3O3S

Molecular Weight: 474.79

MDL number: MFCD00058159

EINECS: 613-721-6

PRODUCT Properties

• Melting point: 159°C (dec.)
• storage temp.: Sealed in dry,2-8°C
• solubility: DMSO or DMF: soluble
• form: powder
• color: White to Off-White
• Merck: 14,1529
• InChI: InChI=1S/C19H17Cl3N2S.HNO3/c20-15-7-4-14(5-8-15)6-9-16(12-24-11-10-23-13-24)25-19-17(21)2-1-3-18(19)22;2-1(3)4/h1-5,7-8,10-11,13,16H,6,9,12H2;(H,2,3,4)
• InChIKey: ZHPWRQIPPNZNML-UHFFFAOYSA-N
• SMILES: C(CN1C=NC=C1)(SC1C(Cl)=CC=CC=1Cl)CCC1=CC=C(Cl)C=C1.[N+]([O-])(=O)O
• CAS DataBase Reference: 64872-77-1(CAS DataBase Reference)

Description and Uses

Butoconazole Nitrate is the nitrate salt form of butaconazole, a synthetic imidazole derivative with fungistatic properties. Butoconazole is an imidazole antifungal agent that completely inhibits the growth of various fungi in vitro when used at concentrations of 0.05-30 μg/ml. It is active against vaginal infections of pure and mixed strains of C. albicans in mice when used vaginally at concentrations of 0.25-2% and 0.1-1%, respectively. Formulations containing butoconazole have been used in the treatment of vaginal yeast infections. Butoconazole Nitrate is an antifungal imidazole antimycotics. It is useful in the topical treatment of vulvovaginal candidiasis, being similar in effectiveness to miconazole and clotrimazole.

Imidazole derivative with antifungal properties

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P301+P312+P330
• Hazard Codes: Xn
• Risk Statements: 22
• WGK Germany: 3
• RTECS: NI4399500
• HS Code: 2933290000
• Toxicity: LD50 in mice, male, female rats (mg/kg): >3200, >3200, 1720 orally; >1600, 940, 940 i.p. (Walker)