Benazepril HCl , ≥99% , 86541-74-4

Synonym(s):
(3S)-3-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid hydrochloride;Benazepril hydrochloride

CAS NO.：86541-74-4

Empirical Formula: C24H29ClN2O5

Molecular Weight: 460.95

MDL number: MFCD01668249

EINECS: 630-414-2

PRODUCT Properties

• Melting point: 188-190°C
• alpha: D -141.0° (c = 0.9 in ethanol)
• storage temp.: 2-8°C
• solubility: DMSO: ~34 mg/mL, soluble
• form: solid
• color: white
• Merck: 14,1031
• InChIKey: VPSRQEHTHIMDQM-FKLPMGAJSA-N
• SMILES: C12=CC=CC=C1CC[C@H](N[C@H](C(=O)OCC)CCC1C=CC=CC=1)C(=O)N2CC(=O)O.Cl |&1:8,10,r|
• CAS DataBase Reference: 86541-74-4(CAS DataBase Reference)

Description and Uses

Benazepril hydrochloride is a long-acting and effective angiotensin-converting enzyme (ACE) inhibitor used to treat essential hypertension. It is the hydrochloride salt form of benazepril, which is a prodrug of benazeprilat. After hepatic cleavage of the ester group, benazepril is converted to benazeprilat. In healthy humans, it was well tolerated and showed no phmacokinetic interactions with furosemide, hydrochlorothiazide, chlorthalidone, digoxin, cimetidine, atenolol, or naproxen.

Benazepril HCl is an angiotensin-converting enzyme (ACE) inhibitors that is commonly used as a sedative, hypnotic, and antihypertensive medication. Benazepril is used alone or together with other medicines to treat high blood pressure (hypertension). It works by reducing the levels of certain chemicals that cause blood vessels to constrict, allowing for smoother blood flow.

Safety

• Symbol(GHS): GHS08
• Signal word: Warning
• Hazard statements: H361fd
• Precautionary statements: P201-P202-P280-P308+P313-P405-P501
• Safety Statements: 22-24/25
• RIDADR: 3077
• WGK Germany: 2
• RTECS: CX7065000
• HS Code: 29337900