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A1342912

6-Biopterin , ≥97% , 22150-76-1

Synonym(s):
(1’R,2’S)-Biopterin;L-erythro-6-(1,2-Dihydroxypropyl)pterin;2-Amino-4-hydroxy-6-(1,2-dihydroxypropyl)pteridine

CAS NO.:22150-76-1

Empirical Formula: C9H11N5O3

Molecular Weight: 237.22

MDL number: MFCD00036787

EINECS: 244-807-8

Pack Size Price Stock Quantity
5MG RMB621.60 In Stock
25MG RMB1599.20 In Stock
100MG RMB4784.00 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: >210°C dec.
alpha  D24 -50° (c = 0.4 in 0.1N HCl); D24 -26° (c = 0.92 in 0.1N NaOH)
Boiling point: 379.74°C (rough estimate)
Density  1.3472 (rough estimate)
refractive index  1.7610 (estimate)
storage temp.  2-8°C
solubility  Aqueous Acid (Slightly, Heated, Sonicated)
form  White to pale yellow powder.
pka 13.18±0.20(Predicted)
color  White to Light Yellow
Merck  13,1229
BRN  87860
Stability: Hygroscopic

Description and Uses

6-Biopterin (L-Biopterin) is the oxidized form of tetrahydro-L-biopterin (BH4), a nitric oxide synthase (NOS) cofactor. L-Biopterin can be reduced to BH4 via thioredoxin reductase followed by dihydropteridine reductase or reduced glutathione. It is extremely toxic to human melanocytes in culture (IC50 = 0.2 μM after 48 hrs). L-Biopterin is rarely found under physiological conditions except in the epidermis of patients with the depigmentation disorder Vitiligo.

L-Biopterin is a pteridine widely distributed in nature; naturally occurring as the L-erythro-form. Considered as a growth factor for some insects. Fluoresces with a blue color in alkaline solution.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
RTECS  UO3506000
10-23
HS Code  29339900
Toxicity sln-par-dmg 10 mg/L MUREAV 128,147,84

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