2-Bromo-5-fluoropyridine , 99% , 41404-58-4

CAS NO.：41404-58-4

Empirical Formula: C5H3BrFN

Molecular Weight: 175.99

MDL number: MFCD00234011

EINECS: 629-269-8

PRODUCT Properties

• Melting point: 30-31 °C (lit.)
• Boiling point: 80-83 °C/44 mmHg (lit.)
• Density: 1.707±0.06 g/cm3(Predicted)
• refractive index: 1.5396
• Flash point: 167 °F
• storage temp.: Inert atmosphere,Room Temperature
• pka: -1.63±0.10(Predicted)
• form: Liquid
• color: Colorless to slightly yellow
• BRN: 1561456
• CAS DataBase Reference: 41404-58-4(CAS DataBase Reference)

Description and Uses

2-Bromo-5-fluoropyridine can be used in the synthesis of the following:

• 5-fluoro-2-phenylpyridine via Suzuki coupling reaction with phenylboronic acid
• 5-fluoro-2-(p-tolyl)pyridine via Suzuki coupling reaction with p-tolylboronic acid

It can undergo palladium-catalyzed homo-coupling reaction to give the corresponding biaryl. It can also be employed in a palladium-catayzed α-arylation of esters leading to 4-pyridylcarboxypiperidines.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P264-P270-P301+P312-P302+P352-P305+P351+P338
• Hazard Codes: Xi,Xn,F
• Risk Statements: 36/37/38-20/21/22-10
• Safety Statements: 26-36-16
• RIDADR: 2811
• WGK Germany: 3
• Hazard Note: Irritant
• HazardClass: 6.1
• PackingGroup: III
• HS Code: 29333990