2-Bromoethanol , Analysis standard , 540-51-2
Synonym(s):
Ethylene bromohydrin
CAS NO.：540-51-2
Empirical Formula: C2H5BrO
Molecular Weight: 124.96
MDL number: MFCD00002827
EINECS: 208-748-1
PRODUCT Properties
| Melting point: | -80 °C |
| Boiling point: | 56-57 °C/20 mmHg (lit.) |
| Density | 1.763 g/mL at 25 °C (lit.) |
| vapor density | 4.3 (vs air) |
| vapor pressure | 2.4 mm Hg ( 20 °C) |
| refractive index | n |
| Flash point: | >230 °F |
| storage temp. | 2-8°C |
| solubility | 1-5 g/100 mL at 19°C |
| form | Liquid |
| pka | 13.82±0.10(Predicted) |
| color | Clear colorless to yellow |
| Specific Gravity | 1.7629 (20/4℃) |
| Water Solubility | 1-5 g/100 mL at 19 ºC |
| Sensitive | Light Sensitive |
| Merck | 14,3792 |
| BRN | 878140 |
| Stability: | Stable, but probably light sensitive. Hygroscopic. Incompatible with strong oxidizing agents. Flammable. Forms an azeotrope with water. |
| InChIKey | LDLCZOVUSADOIV-UHFFFAOYSA-N |
Description and Uses
2-bromoethanol, a halogenated alipathic hydrocarbon, is a widely used industrial chemical. It is also a contaminant in food such as wheat and flour during treatment with ethylene oxide. 2-Bromoethanol was also found as a metabolite of 1,2-dibromoethane. A known carcinogen in experimental animals. 2-Bromoethanol is highly toxic in vivo and is a potent mutagen. Fatty acid conjugates of 2-bromoethanol that have been identified after 2-bromoethanol administration to rats may explain the long term 2-bromoethanol accumulation and retention in body tissues. Chronic exposure to 2-bromoethanol causes liver and kidney toxicity. 2- Bromoethanol also induces extensive lipid peroxidation in rat liver, kidney and testis slices and inhibits liver mitochondria respiration[1].
2-Bromoethanol is used in selective reduction of nitroarenes (PcFe(II)/NaBH4/2-bromoethanol catalyst system). It is not used much forany commercial purpose. The risk of exposure to this compound arises when ethylene oxide reacts with hydrobromic acid. It is used as a solvent and organic synthetic raw material. 2-Bromoethanol finds application in the synthesis of 2-piperidin-1-yl-ethanol by reacting with piperidine.
Safety
| Symbol(GHS) |   GHS05,GHS06 |
| Signal word | Danger |
| Hazard statements | H301+H311+H331-H314 |
| Precautionary statements | P280-P301+P310+P330-P301+P330+P331-P303+P361+P353-P304+P340+P311-P305+P351+P338 |
| Hazard Codes | T,T+,Xn,F |
| Risk Statements | 23/24/25-34-40-36/37/38-26/27/28-10-67-65-48/20-38-11-63 |
| Safety Statements | 26-36/37/39-45-28A-16-62-36/37 |
| RIDADR | UN 2922 8/PG 2 |
| WGK Germany | 3 |
| RTECS | KJ8225000 |
| TSCA | Yes |
| HazardClass | 6.1 |
| PackingGroup | II |
| HS Code | 29055900 |
