1-Bromo-3-chloropropane , 99% , 109-70-6

Synonym(s):
1-Bromo-3-chloropropane;1-Chloro-3-bromopropane;I-BCP;Trimethylene bromochloride;Trimethylene chlorobromide

CAS NO.：109-70-6

Empirical Formula: C3H6BrCl

Molecular Weight: 157.44

MDL number: MFCD00000998

EINECS: 203-697-1

Update time: 2022-07-08

PRODUCT Properties

Melting point:	-59 °C
Boiling point:	144-145 °C (lit.)
Density	1.592 g/mL at 25 °C (lit.)
vapor pressure	7.5 hPa (20 °C)
refractive index	n20/D 1.486(lit.)
Flash point:	81 °C
storage temp.	room temp
solubility	2.24g/l insoluble
form	liquid
color	Clear liquid
explosive limit	3.2-8.6%(V)
Water Solubility	insoluble
BRN	605278
Stability:	Volatile

Description and Uses

1-Bromo-3-chloropropane is a halogenated alkane compound containing one bromine atom and one chlorine atom in its structure. Due to the high electronegativity of halogens, the molecule of 1-Bromo-3-chloropropane is highly electrophilic and is easily attacked by electrophilic reagents such as nucleophilic reagents, Lewis acid, etc., which undergoes nucleophilic substitution reactions. The compound is relatively stable at room temperature, but is susceptible to elimination reactions at high temperatures or in the presence of strong acids or bases. In addition, prolonged exposure to air should be avoided because 1-Bromo-3-chloropropane molecules contain halogen atoms that are susceptible to reaction by oxygen and moisture in the air to produce products such as alcohols and aldehydes.

1-Bromo-3-chloropropane is used in the preparation active pharmaceutical ingredient intermediate such as gemfibrozil and reproterol. It is also involved in the preparation of cardiovascular diseases and analgesic drugs materials. It is utilized as a phase separation reagent for the isolation of ribonucleic acid (RNA) in high quality. It is considered as a replacement of chloroform in nucleic acid separations.

Safety

Symbol(GHS)	GHS06,GHS08
Signal word	Danger
Hazard statements	H302-H331-H335-H341-H350-H360FD-H412
Precautionary statements	P202-P261-P273-P301+P312-P304+P340+P311-P308+P313
Hazard Codes	Xn
Risk Statements	10-22-36/37/38-20/21/22-20/22-68-52/53-37
Safety Statements	16-45-36/37/39-26
RIDADR	UN 2688 6.1/PG 3
WGK Germany	3
RTECS	TX4113000
TSCA	Yes
HazardClass	6.1
PackingGroup	III
HS Code	29034980
Toxicity	LD50 orally in Rabbit: 1100 - 1200 mg/kg LD50 dermal Rat > 2000 mg/kg