A1046312
Adriamycin , 97% , 23214-92-8
CAS NO.：23214-92-8
Empirical Formula: C27H29NO11
Molecular Weight: 543.53
MDL number: MFCD00869292
EINECS: 245-495-6
| Pack Size | Price | Stock | Quantity |
| 25MG | RMB399.20 | In Stock |
|
| 100MG | RMB1007.20 | In Stock |
|
| 500MG | RMB3199.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 205°C |
| Boiling point: | 617.77°C (rough estimate) |
| Density | 1.3783 (rough estimate) |
| refractive index | 1.6400 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,2-8°C |
| solubility | ≥27.2 mg/mL in DMSO; insoluble in EtOH; ≥24.8 mg/mL in H2O with ultrasonic |
| form | solid |
| pka | pKa 8.2 (Uncertain) |
| Water Solubility | Soluble |
Description and Uses
Doxorubicin is one of the most effective neoplastic drugs, and is mainly used in combination with other drugs for treating solid tumors. This drug is used for leukemia, various sarcomas, practically every type of cancer, neuroblastomas, leukoses, and lymphomas.
Safety
| Symbol(GHS) |   GHS07,GHS08 |
| Signal word | Danger |
| Hazard statements | H302-H315-H319-H335-H350-H362 |
| Precautionary statements | P260-P263-P280 |
| HS Code | 2941900000 |
| Toxicity | An anthracycline cytotoxic antineoplastic that is produced by Streptomyces peucetius. The LD50 in mice is 9.4 mg/kg, i.v. It is a carcinogen that inhibits DNA and RNA synthesis by intercalating in double-stranded DNA with the amino sugar in the minor groove and the 90-OH group of the anthracycline ring hydrogen-bonded to the adjacent guanine. It also alters membrane fluidity and ion transport, and generates free radicals through a cytochrome P450-mediated reductive process. In humans, it causes alopecia, stomatitis, nausea, vomiting, diarrhea, cardiotoxicity (manifested by tachycardia), and potentially fatal congestive heart failure. |
