GBR12909dihydrochloride , ≥98% , 67469-78-7

Synonym(s):
1-(2-[bis(4-Fluorophenyl)methoxy]ethyl)-4-(3-phenylpropyl)piperazine dihydrochloride;1-(2-Bis(4-fluorophenyl)methoxy)ethyl)-4-(3-phenylpropyl)piperazine Hydrochloride, Dopamine Active Transporter Inhibitor, GBR 12909, DAT Inhibitor, GBR 12909, GBR12909;GBR 12909 Dihydrochloride - CAS 67469-78-7 - Calbiochem

CAS NO.：67469-78-7

Empirical Formula: C28H33ClF2N2O

Molecular Weight: 487.03

MDL number: MFCD00055193

PRODUCT Properties

• Melting point: 221 °C
• storage temp.: Sealed in dry,Room Temperature
• solubility: DMSO: >5 mg/mL Solutions freshly prepared daily
• form: solid
• color: white
• Water Solubility: Soluble in DMSO to 50mM. Soluble to 5mM in water with warming.
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.

Description and Uses

Vanoxerine dihydrochloride (GBR-12909 dihydrochloride) is a potent inhibitor that blocks dopamine uptake (IC50 = 1-51 nM). It is more than 100-fold less effective at blocking serotonin or noradrenaline uptake. GBR 12909 effectively inhibits dopamine uptake in vivo, leading to consequent stimulation of dopamine receptors. GBR 12909 also inhibits pyrilamine binding to the histamine H1 receptor (IC50 = 18 nM) but poorly inhibits ligand binding to dopamine, adrenergic, acetylcholine, serotonin, and γ-aminobutyric acid receptors. It also blocks ligand binding to sigma receptors in rat brain (IC50 = 48 nM).

Vanoxerine dihydrochloride is a Dopamine reuptake inhibitor that is developed for treatment of Parkinson's disease and depression but has no effect on these diseases.

Safety

• WGK Germany: 3
• HS Code: 2933.59.5300