SP-2509 , ≥98% , 1423715-09-6

Synonym(s):
BHC110 Inhibitor VII, Histone Lysine Demethylase Inhibitor XIV, KIAA1718 Inhibitor VII, LSD Inhibitor VII, SP-2509;LSD1 Inhibitor VII, SP-2509 - CAS 1423715-09-6 - Calbiochem

CAS NO.：1423715-09-6

Empirical Formula: C19H20ClN3O5S

Molecular Weight: 437.9

MDL number: MFCD28348370

PRODUCT Properties

• Density: 1.44±0.1 g/cm3(Predicted)
• storage temp.: +2C to +8C
• solubility: Soluble in DMSO (up to at least 25 mg/ml)
• form: Off-white solid
• pka: 7.96±0.43(Predicted)
• color: White
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Description and Uses

SP2509 (1423715-09-6) is a potent (IC50 = 13 nM) and reversible inhibitor of the histone demethylase LSD1 (KDM1A).1 It is inactive against the closely related flavin enzymes MAO A,B as well as lactate dehydrogenase, several CYP’s and hERG. LSD1 regulates the balance between self-renewal and differentiation of stem cells and is highly expressed in various cancers.2-6 SP2509 promotes autophagy in neuroblastoma cells.7

SP 2509 reduces the effect of the LSD1 binding to CoREST, resulting in increased methylation of H3K4 and driving increased expression of p21, p27 and CCAAT/enhancer binding protein α in acute myeloid leukemia cells. Anti-leukemia agent.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315
• Precautionary statements: P264-P280-P302+P352-P332+P313-P362+P364