Home Categories Biochemical Engineering amino(3-oxo-2,3-dihydro-1,2-oxazol-5-yl)aceticacid
A0810312

amino(3-oxo-2,3-dihydro-1,2-oxazol-5-yl)aceticacid , ≥95% , 2552-55-8

Synonym(s):
α-Amino-3-hydroxy-5-isoxazoleacetic acid;2-amino-2-(3-hydroxyisoxazol-5-yl) acetic acid, α-Amino-(3-hydroxy-5-isoxazolyl)acet­ic acid, Glutamate Receptor Agonist, Ibotenic acid;Ibotenic Acid - CAS 2552-55-8 - Calbiochem

CAS NO.:2552-55-8

Empirical Formula: C5H6N2O4

Molecular Weight: 158.11

MDL number: MFCD00069294

Pack Size Price Stock Quantity
1MG RMB255.20 In Stock
5MG RMB839.20 In Stock
10mg RMB1423.20 In Stock
25MG RMB3359.20 In Stock
50mg RMB6079.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 141-147 °C
Density  1.621±0.06 g/cm3 (20 ºC 760 Torr)
storage temp.  Keep in dark place,Inert atmosphere,Room temperature
solubility  H2O: soluble1mg/mL, clear, colorless (with sonication)
form  White solid
pka 2.16±0.10(Predicted)
color  white
Odor Practically odorless. Faint, meat-like, mild and sweet taste in aqueous dilutions.
Water Solubility  Soluble to 10 mM in water and to 100 mM in 1.1eq. NaOH
Stability: Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month.
InChIKey IRJCBFDCFXCWGO-UHFFFAOYSA-N
LogP -1.070 (est)
CAS DataBase Reference 2552-55-8(CAS DataBase Reference)

Description and Uses

Ibotenic acid (60573-88-8) is a conformationally restricted analog of glutamate which occurs naturally in Amanita mascaria and related mushrooms.? It is a non-specific glutamate receptor (both NMDA and mGluR) agonist.1 May be used to induce hippocampal lesioning in rat neurodegeneration models.2,3 Induces lesions in the subiculum in a mouse model of Alzheimer’s disease.4

Ibotenic acid is a neuroexcitatory amino acid originally isolated from Amanita species that functions as a NMDA and metabotropic glutamate receptor agonist. As a neurotoxin, ibotenic acid is often used to induce brain lesions in animals that model cognitive dysfunctions resulting from neurodegenerative diseases, traumatic brain injury, and stroke.

Safety

Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P264-P270-P301+P310-P405-P501
Hazard Codes  T,Xn
Risk Statements  23/24/25-25-40
Safety Statements  45-38-36/37/39-28A-22-36
RIDADR  1544
WGK Germany  3
RTECS  NY2100000
HazardClass  6.1(b)
PackingGroup  III
Toxicity LD50 in mice, rats (mg/kg): 15, 42 i.v.; 38, 129 orally (Theobald)

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